Alpha-1 antichymotrypsin

FIGURE 4.29 MFH labels for several determinants that are associated with mononuclear phagocytic cells, such as alpha -antichymotrypsin, as shown here. However, those markers are completely non-specific, and it is much more important to undertake systematic elimination of several lineage-related markers as the first step in the diagnosis of MFH. 

CNS, central nervous system CFAP, glial fibrillary acid protein a-ACT, alpha-antichymotrypsin Ig, immunoglobulin ECA, leukocyte common antigen RBC, red blood cell. 

Parentheses around a differential feature indicate an uncommon feature that is very useful in differential diagnosis when found. a-ACT, alpha-antichymotrypsin CNS, central nervous system CP cerebellopontine EMA, epithelial membrane antigen GFAP, glial fibrillary acidic protein IGF-II, insulin-like growth factor II. 

Chen, Z., Prestigiacomo, A., Stamey, T. Purification and characterization of prostate-specific antigen (PSA) complexed to alpha-1 antichymotrypsin Potential reference material for international standardization of PSA immunoassays. Clin. Chem. 41, 1273-1282 (1995). 

Tysoe, C., Galinsky, D., Robinson, D., et al. (1997) Analysis of alpha-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia. Am. J. Med. Genet., 74, 207-212. 

Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O. A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer Assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991 51 222-226. 

Lilja H, Christensson A, Dahlen U, et al. Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. Clin Chem 1991 37 1618-1625. 

Christensson A, Bjork T, Nilsson O, et al. Serum prostate specific antigen complexed to alpha 1-antichymotrypsin as an indicator of prostate cancer. J Urol 1993 150 100-105. 

Hutchinson S, Luo LY, Yousef GM, Soosaipillai A, Diamandis EP. Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(l)-antichymotrypsin. Clin Chem 2003 49 746-751. 

Huang Y, Herman MM, Liu J, et al. 1997. Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer s disease share immunoreactivity for amyloid precursor protein, A beta, alpha 1-antichymotrypsin and ubiquitin-protein conjugates. Brain Res 771 213-220. 

B14. Beatty, K., Bieth, J., and Travis, J., Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J. Biol. Chem. 255, 3931-3934 (1980). 

Yoon, D., Kueppers, F., Genta, R.M., Klintmalm, G.B., Khaoustov, VJ., Yoffe, B. Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-l-antitrypsin deficiency phenotype SZ (case report). Gut 2002 50 730—732... 

DuBoulay GEH. Demonstration of alpha-1-antitrypsin and alpha-1-antichymotrypsin in fibrous histiocytomas using the immunoperoxidase technique. Am J Surg Pathol. 1982 6 559-564. 

Abraham, C. R., Selkoe, D. J., and Potter, H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer s disease. Cell 52 (1988) 487-501. 

Alkaline Phosphatase (bone) Alpha-l,3-fticosyltransferase (FUT6) Alpha-1-acid Glycoprotein Alpha-1 -antichymotrypsin Alpha-1 -antitrypsin Alpha-IB glycoprotein Alpha-1 -microglohulin Alpha-2-antiplasmin Alpha-2-HS glycoprotein Alpha-2-macroglohulin Alpha-fetoprotein Amylase (pancreatic)... 

Bilak M, Askanas V, Engel WK. (1994) Alpha 1-antichymotrypsin is strongly immunolocalLzed at normal human and rat neuromuscular junctions. Synapse 16, 280-283. 

Iron imbalance, like Inflammation, has been recognized genetically in the etiology of neurological disorders. Consistent with these observations, the acute phase protein, alpha-1 antichymotrypsin [32] is associated with amyloid plaques and the iron storage protein ferritin is present in neuritic plaques [33,34]. 

Nilsson LN, B.K., DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H., Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer s disease. J Neurosci, 2001.21(5) p. 1444-51. 

Abraham, C.R., et al.. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience, 1989.32(3) p. 715-20. 

Cichy J, Potempa J, Chawla RK, Travis J. Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells. J Clin Invest 1995 95 2729-2733. 

Lindmark B. Asthma and heterozygous alpha 1-antichymotrypsin deficiency a possible association. J Intern Med 1990 227 115-118. 

Lindmark B, Svenonius E, Eriksson S. Heterozygous alpha 1-antichymotrypsin and... 

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