Alpha, 1-glycoprotein

Kuribayashi, T., M. Shimizu, T. Shimada, T. Honjyo,Y. Yamamoto, K. Kuha, and S. Yamamoto. 2003. Alpha 1 -glycoprotein in healthy and pregnant heagle dogs. Experimental Animals 52 377-381. 

Ropivacaine is 94% bound to alpha-1 glycoprotein and is mainly protein-bound. After intravascular infusion, steady-state volume of distribution is 41 ht-ers. In addition, ropivacaine readily crosses the placenta and unbound concentration equilibrium is quickly reached. The degree of plasma protein binding in the fetus is less than in the mother. This results in lower total plasma concentrations in the fetus than in the mother. The ratios of umbilical vein to maternal vein total and free concentrations are 0.31 and 0.74, respectively. 

There are several positive factors using BSA in the basolateral medium. First, it mimics the in vivo situation where the circulating blood provides an excellent base for sink conditions due to a large volume and content of serum proteins such as albumin (serum protein content and alpha-glycoproteins) [108]. Second, serum albumin hinders adsorption onto plastic surfaces and filters and thereby stops the... 

Racemic methadone (MET) is administered to heroin addicts as a substitution therapy. However, methadone enantiomers possess different pharmacological effects, and the drug has been demonstrated to be enantioselectively metabolized to its two major metabolites, 2-ethylidene-l,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-l-pyrroline (EMDP). Stereoselective separation of MET, EDDP, and EMDP using an alpha-glycoprotein stationary phase and MS-MS detection was proposed by Kelly et al. [34]. Optimal separation conditions were 20 mM acetic acid isopropanol (93 7, pH 7.4), with a flow rate of 0.9mL/min. 

Erythropoietin, an alpha glycoprotein, appearing in the blood of mammals in conditions of hypoxia and stimulating the proliferation of red bone marrow, has not yet been obtained in pure samples. 

Chiral-AGP alpha-acid glycoprotein bonded to silica. 

Corfleld AP, Schauer R (1982) Metabolism of sialic acids. In Schauer R (ed) Sialic acids - Chemistry, metabolism and function. Springer, Wien, pp 195-261 Corfleld AP, Higa H, Paulson JC, Schauer R (1983) The specificity of viral and bacterial sial-idases for alpha(2-3)- and alpha(2-6)-linked sialic acids in glycoproteins. Biochim Biophys Acta 744 121-126... 

F. Bree, G. Houin, J. Barre, J. L. Moretti, V. Wirquin, and J.-P. Tillement, Pharmacokinetics of intravenously administered 125I-labelled human alpha-1-acid glycoprotein, Clin. Pharmacokinet, 11, 336-342 (1986). 

C. G. Gahmberg and L. C. Anderson, Leucocyte surface origin of human alpha-1-acid glycoprotein (oroso-mucoid), J. Exp. Med, 148, 507-521 (1978). 

Chatterjee M, Harris AL (1990) Reversal of acquired resistance to adriamycin in CHO cells by tamoxifen and 4-hydroxy tamoxifen role of drug interaction with alpha 1 acid glycoprotein. Br J Cancer 62(5) 712-717... 

L6. Laurell, A.-B., Influence of alpha-streptococci, pneumococci and Pasteurella pseudotuberculosis on human serum glycoproteins. Acta Pathol, et Microbiol. Scand. 47, 429 (1959). 

CXi globulins a lipoprotein (apoA) CXi-antitrypsin Alpha fetoprotein CXi acid glycoprotein... 

Patel J, Pal D, Vangal V, Gandhi M, Mitra AL (2002) Transport of HIV-protease inhibitors across 1 alpha,25 di-hydroxy vitamin D3-treated Calu-3 cell monolayers Modulation of P-glycoprotein activity. Pharm Res 19(11) 1696-1703. 

Hartz AM, Bauer B, Fricker G, Miller DS (2006) Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol Pharmacol 69 462 -70... 

Finally, nucleolin has also been identified as a repressor of polymerase II transcription (Yang et al 1994). Biochemical and functional studies further established that nucleolin is a transcription repressor for regulation of alpha-1 acid glycoprotein (AGP)... 

Li, S., and Lloyd, D. K. (1993). Direct chiral separations by capillary electrophoresis using capillaries packed with an alpha(l)-acid glycoprotein chiral stationary phase. Anal. Chem. 65,... 

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