Allergy inhibitors synthesis

Holgate ST, Bradding P, Sampson AP. Leukotriene antagonists and synthesis inhibitors new directions in asthma therapy. J Allergy Clin Immunol 1996 98 1-13. 

Pipkorn, U. el al. (1987) The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction. Allergy. 42.496 501. 

In order to determine the physiological roles of various prostanoid receptors a number of knockout mice have been developed [18]. These studies indicate that prostacyclin receptors are involved in at least some types of pain responses, EP3 receptors are involved in the development of fever, EP2 and EP4 function in allergy and bone resorption, and EPl receptors are involved in chemically induced colon cancer. The availability of cloned prostanoid receptors provides a rational and the appropriate technology to search for receptor agonists and antagonists that might provide some specificity beyond the currently available COX inhibitors, which prevent broadly the synthesis of all PGs. 

This phenomenon is not a true allergy, nor is it specifically caused by aspirin. It is the result of decreased synthesis of bronchodilatory prostanoids in the lung. In susceptible individuals, prostaglandin synthesis inhibitors may inhibit the synthesis not only of inflammatory prostanoids, but also of those prostanoids that contribute to patent airways. Thus, sensitivity to prostaglandin synthesis inhibitors can precipitate bronchoconstriction and blockade of airways. These events can arise from increased dosing of NSAIDs, increased frequency of dosage, or concurrent administration of more than one drug (e.g.. naproxen with ibuprofen). 

First-generation cephalosporin prototype bactericidal beta-lactam inhibitor of cell wall synthesis. Active against gram-positive cocci, E coli, K pneumoniae. but does not enter CSF. Tox potential allergy partial cross-reactivity with penicillins. 

Antibiotic carbapenem active against many aerobic and anaerobic bacteria, including penicillinase-producing organisms a bactericidal inhibitor of cell wall synthesis. Used with cilastatin (which inhibits metabolism by renal dehydropeptidases). Tox allergy (partial cross-reactivity with penicillins), seizures (overdose). Meropenem is similar but does not require cilastatin. 

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