Prostaglandin synthesis inhibitors

Jager AK, Hutchings A, van Staden J. Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors.] Ethnopharmacol 1996 52 95-100. 

Young I can explain ATP. I did these experiments looking at intercellular Ca2+ waves and apyrase, and there is no effect. It turns out that the presence of either a prostaglandin transporter blocker, which is the same class as a Cl channel blocker, or a prostaglandin synthesis inhibitor, interrupts intracellular Ca2+ that is far away. It does not interrupt the intercellular Ca2+ through the gap junctions there are two different mechanisms. 

Certain other drugs also having uterine relaxant property are calcium channel blockers, prostaglandin synthesis inhibitors, progesterone, nitrites, anticholinergics, ethyl alcohol etc. 

Additive - the drugs have the same biochemical mechanism and will react with the target cells as long as receptor sites are available. Examples are the cyclooxygenase inhibitors (prostaglandin synthesis inhibitors) aspirin and acetaminophen (Tylenol ), antihypertensives propanolol and the rauwolfia alkaloids. 

Fluonnated agents such as flurbiprofen (11), flunisal(I2), diflunisal (13), and sulindac (14), acting as prostaglandin synthesis inhibitors, have been available for some time [5] The recent introduction of flunoxaprofen (IS), a lipoxygenase inhibitor, is notable It reportedly produces considerably less severe gastric disturbance [23]... 

Our ancestors were, of course, ignorant of the neurobiology of opiates or prostaglandin synthesis inhibitors. In the distant past, when a person felt pain—particularly in the absence of evidence of injury—spiritual healers or medicine men developed fanciful myths to explain the cause of the pain, treated it with a decoction from the willow tree or myrrh shrub, and were often rewarded with elevated positions in their communities when their treatments seemed to magically make the pain go away and produced such an intense feeling of joy at the same time. With the advance of modern science, we know more about the mechanisms of pain and about the reasons why some drugs are better at treating it than others. 

Gans KR, Galbraith W, Roman RJ, Haber SB, Kerr JS, Schmidt WK, Smith C, Hewes WE, Ackerman NR. Antiinflammatory and safety profile of DuP697, a novel orally effective prostaglandin synthesis inhibitor. J. Pharmacol. Exp. Then, 1990, 254, 180-187. 

Of the estimated annual 65 000 upper gastrointestinal emergency admissions in the UK, nearly 20% (including deaths in 3.4%) are attributable to the use of prostaglandin synthesis inhibitors (42). As might be expected with an inhibitor of prostaglandin synthesis, the cyto-protective effects of prostaglandin E and prostacyclin... 

Chronic sahcylate intoxication is commonly associated with chronic daily headaches, lethargy, confusion, or coma. Since headache is a feature, it can easily be misdiagnosed if the physician is not aware that aspirin has been over-used. Depression of mental status is usually present at the time of diagnosis, when the serum salicylate concentration is at a peak. The explanation of depression, manifested by irritability, lethargy, and unresponsiveness, occurring 1-3 days after the start of therapy for aspirin intoxication, lies in a persistently high concentration of salicylate in the central nervous system, while the serum salicylate concentration falls to non-toxic values. The delayed unresponsiveness associated with sahcylate intoxication appears to be closely associated with the development of cerebral edema of uncertain cause. The encephalopathy that ensues appears to be directly related to increased intracranial pressure, a known effect of prostaglandin synthesis inhibitors it responds to mannitol (98). 

Simeoni U, Messer J, Weisburd P, Fladdad J, Willard D. Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors. Eur J Pediatr 1989 149 371-373. 

Prostaglandin synthesis inhibitors Chemicals that alter cyclic nucleotide levels Glutathione... 

Analysis of the analgesic and anti-inflammatory effects of rimazolium, a pyrido-pyrimidine derivative, compared with that of prostaglandin synthesis inhibitors and morphine... 

Effect of some prostaglandin synthesis inhibitors on the antinociceptive action of morphine in albino rats Srivastava, D. N. Bhattacharya, S. K. Sanyal, A. K. 

This phenomenon is not a true allergy, nor is it specifically caused by aspirin. It is the result of decreased synthesis of bronchodilatory prostanoids in the lung. In susceptible individuals, prostaglandin synthesis inhibitors may inhibit the synthesis not only of inflammatory prostanoids, but also of those prostanoids that contribute to patent airways. Thus, sensitivity to prostaglandin synthesis inhibitors can precipitate bronchoconstriction and blockade of airways. These events can arise from increased dosing of NSAIDs, increased frequency of dosage, or concurrent administration of more than one drug (e.g.. naproxen with ibuprofen). 

Prostaglandin synthesis inhibitors and vasa recta erythrocyte velocities in the rat. Am. J. Physiol, 247, F562-F567... 

Ganguli, M., Tobian, L., Azar, S. and O Donnell, M. (1977). Evidence that prostaglandin synthesis inhibitors increase the concentration of sodium and chloride in rat renal medulla. Circ. Res., 40, (suppl 1), 135-139... 

Zimmerman, B.G., Ryan, M.J., Corner, S. and Kraft, E. (1973). Effect of prostaglandin synthesis inhibitors indomethacin and eicosa-5,8,ll,14-tetraynoic acid on adrenergic responses in dog cutaneous vasculature. ]. Pharmacol Exp. Ther., 187, 315-323... 

Beilin, L.J. and Bhattacharya, J. (1977). The effect of prostaglandin synthesis inhibitors on renal blood flow distribution in conscious rabbits. ]. Physiol, 269, 395-405... 

Paracetamol many worldwide 10.8 53,200 Prostaglandin synthesis inhibitor Fever, painkiller... 

Carter, C.A., Ip, M.M., and Ip, C. (1987) Response of Mammary Carcinogens to Dietary Linoleate and Fat Levels and Its Modulation by Prostaglandin Synthesis Inhibitors, in Polyunsaturated Fatty Acids ami Eicosanoids (Lands, W.E.M., ed.) pp. 253-260, ACXJS Press, Champaign, IL. 

Coceani, F., Olley, P. M., Bodach, E., 1975 Lamb ductus arteriosus effect of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandins E2. Prostaglandins 9, 299-308. 

Eriksson, S., Hagenfeldt, L., Law, D., Patrono, C., Birica, E., Wennmalm, A., 1983 Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide stimulated cerebral blood flow in man. Acta Physiol. Scand. 117, 203-211. 

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