Allergy aspirin sensitivity

Corrigan C, Mallett K, Ying S, et al. (2005) Expression of the cysteinyl leukotriene receptors cysLT(l) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis. J Allergy Clin Immunol. 115, 316-322. 

IL-5 is usually not present in high levels in humans. However, in a number of disease states where the number of eosinophils is elevated, high levels of IL-5 and its mRNA can be found in the circulation, tissue and bone marrow. These conditions include the diseases of the respiratory tract, hematopoietic system, gut and skin. Some other examples include food and drug allergies, atopic dermatitis, aspirin sensitivity and allergic or nonallergic respiratory diseases. 

Kowalski ML. Aspirin sensitive rhinosinusitis and asthma. Allergy Proc 1995 16 77-80. 

Pleskow WW, Stevenson DD, Mathison DA, Simon RA, Schatz M, Zeiger RS. Aspirin desensitization in aspirin-sensitive asthmatic patients clinical manifestations and characterization of the refractory period. J Allergy Clin Immunol 1982 69(1 Pt 1) 11-19. 

Stevenson DD, Simon RA. Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. J Allergy Clin Immunol 2001 108(1) 47-51. 

Settipane RA, Stevenson DD. Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. J Allergy Clin Immunol 1989 84(l) 26-33. 

Paul JD, Simon RA, Daffern PJ, et al. Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics. Ann Allergy Asthma Immunol 2000 85 40-45. 

Vicks SD, Dean JR, Tenholder MF. Ketorolac-induced respiratory failure in an aspirin-sensitive asthmatic, limnunol Allergy Tract 1991 13 23—25. 

Other toxic effects of NSAIDs include hypersensitivity reactions, rash, and central nervous system complaints of drowsiness, dizziness, headaches, depression, confusion, and tinnitus. Although NSAIDs are generally avoided in patients with asthma who are aspirin-intolerant, studies indicate that celecoxib and rofecoxib are well tolerated in aspirin-sensitive asthma, providing a viable option for these patients. Celecoxib and valdecoxib are sulfonamides and are thus contraindicated for those with sulfa allergies. 

Perez-Novo CA, Kowalski ML, Kuna P, et al Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis studies on the relationship. Int Arch Allergy Immunol 2004 133 255-260. 

Czemiawska-Mysik G, Szczeklik A (1980) Allergy to pyrazolone drugs. Acta Med Pol Delaney JC (1973) Asthma, nasal polyposis and aspirin sensitivity. Ann Intern Med 79 761 Delaney JC (1976) The effect of sodium cromoglycate on analgesic-induced asthmatic reactions. Clin Allergy 6 365-370... 

Partridge MR, Gibson GJ (1978) Adverse bronchial reactions to intravenous hydrocortisone in two aspirin-sensitive asthmatic patients. Br Med J 10 1521-1522 Pelikan Z (1978) Possible immediate hypersensitivity reaction of the nasal mucosa to oral contraceptives. Ann Allergy 40 211-219... 

Chiu, J. T., 1983, Improvement in aspirin-sensitive asthmatic subjects after rapid aspirin desensitization and aspirin maintainance (ADAM) treatment, J. Allergy Clin. Immunol. 71 560. 

Koschei D, Cardoso C, Leucht V, Hoffken G. Asthmatic reaction induced by Etoricoxib in a patient with aspirin-sensitive asthma. Allergy 2008 63(8) 1093-4. 

Caplin, I. (1976) Diabetes mellitus and insulin in an aspirin sensitive asthmatic. Ann. Allergy, 36, 193. 

Stevenson DD. Aspirin and NSAID sensitivity. Immunol Allergy Clin North Am. 2004 24 491-505. 

The following patient categories were excluded from the study patients with ostial and bifurcation lesions, left ventricular ejection fraction <30%, known hypersensitivity or contraindication to aspirin or stainless steel, or a sensitivity to contrast dye, allergy to heparin or ticlopidine,... 

Stevenson DD, Simon RA, Zuraw BL. Sensitivity to aspirin and nonsteroidal anh-inflanunatory drags. In Adkinson NE Jr, Yunginger JW, BusseWW, etal, eds. Allergy Principles and Practice, Vol 2,6th ed. 2003 1695-1710. 

This phenomenon is not a true allergy, nor is it specifically caused by aspirin. It is the result of decreased synthesis of bronchodilatory prostanoids in the lung. In susceptible individuals, prostaglandin synthesis inhibitors may inhibit the synthesis not only of inflammatory prostanoids, but also of those prostanoids that contribute to patent airways. Thus, sensitivity to prostaglandin synthesis inhibitors can precipitate bronchoconstriction and blockade of airways. These events can arise from increased dosing of NSAIDs, increased frequency of dosage, or concurrent administration of more than one drug (e.g.. naproxen with ibuprofen). 

Fischerman EW, Cohen GN (1973) Aspirin and other cross-reaction small chemicals in known aspirin-intolerant patients. Ann Allergy 31 476-484 Fischerman EW, Cohen GN (1977) Chronic and recurrent urticaria new concepts of drug-group sensitivity. Ann Allergy 39 404-414... 

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