Allergic reactions drug induced

A retrospective analysis of allergic reactions (drug-induced fever and rash) in 90 adults with cystic fibrosis, of whom 26 developed probable allergic reactions to parenteral beta-lactams. There was drug-induced fever in 54 and skin reactions in 28 of 897 treatment courses (6 and 3.1% respectively). There was one case of non-fatal anaphylaxis. The numbers of allergic reactions per number of patients receiving specific antibiotics were carbenicillin 4/56, mezlocillin 7/42, piperacillin 11/31, ticarcUlin 1/20, cefazolin 0/24, ceftazidime 1/35, imipenem + cilastatin 4/16, and nafcillin 3/36 (17). 

General Indication Allergic disorders Principal Desired of Glucocorticoids Decreased inflammation Examples of Specific Disorders Anaphylactic reactions, drug-induced allergic reactions, severe hay fever, serum sickness... 

The most common clinical picture of non-immediate RCM reactions is a macu-lopapular exanthema, which resembles other drug-induced T-cell-mediated hypersensitivity reactions. The reported onset of skin eruptions 2-10 days after the first exposure to a RCM and 1-2 days after re-exposure to the same substance is typical for an allergic drug reaction with a sensitization phase. 

With IV CyC - - 5FU - - MTX it cannot be established which IMN in the combination is effective and which induces adverse effects. Immediate allergic reactions arising during IV drips may indicate the IMN concerned. Drug interactions among 5FU, MTX and CyC by IVT and oral CyS, MMF, and MTX have not been studied. It has been established however that quinolone antibiotics may interact with IMNs. 

Allergic reactions manifesting as fever, urticaria or other rashes, and arthralgia occur in 1-5% of patients taking antithyroid drugs. There has been a report of thiamazole-induced hypersensitivity syndrome associated with reactivation of human herpes virus 6 and cytomegalovirus (57). 

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