Alkaloids literature

The earlier alkaloid literature contains numerous reports of studies aimed at discovering the existence of chemotypes involving these pharmacologically important compounds. An example of this sort of study comes from the work of Karnick and Saxena (1970) who were interested in the effect of elevation on total alkaloid content of Datura metel L. (Solanaceae), an important source of hyoscyamine [26]... 

The regular team of authors reviews the whole of the alkaloid literature for the year and a two-year coverage of Erythrina alkaloids is included. 

The intention of the eighth volume of The Alkaloids was once again to provide a comprehensive annual survey of the alkaloid literature. It has not been possible, however, to include chapters on the Tropane Alkaloids and on Miscellaneous Alkaloids, and certain aspects of the chemistry of isoquinoline alkaloids have been omitted we expect to remedy these deficiencies by including a two-year coverage in Volume 9. 

Gene regulation represents the most basic level of metabolic control. Although there are few examples in the alkaloid literature, the post-translational regulation of enzymes can also exert considerable influence over the control of metabolic flux. Recent work in our laboratory suggests that enzymatic controls function of the regulation in alkaloid biosynthesis. (5)-Norcoclaurine is accepted as the central precursor to all BAs produced in plants.6,7 However, NCS was first isolated based on its ability to convert dopamine and 3,4-dihydroxyphenylacetaldehyde (3,4-DHPAA) to the tetrahydroxylated alkaloid (S)-norlaudanosoline.129 The ability of NCS to accept either 4-HPAA or 3,4-DHPAA contributed to the incorrect conclusion that (S)-norlaudanosoline is a common pathway intermediate. However, only (5)-norcoclaurine has been detected in plants. 

The presentation here has been primarily concerned with the synthetic relationships between the dimeric calabash-curare alkaloids. Literature is only cited when it is not contained in the recently published review articles. In these works all the arguments leading to the structural classification of the alkaloids are fully discussed and the important contributions of the schools of H. Wieland and P. Karrer indicated. 

The alkaloid literature has been reviewed up to the end of June 1970, but for convenience most authors have started their literature surveys from January 1969 this inaugural volume, therefore, properly represents a summary of developments in the subject during an eighteen-month period. The whole field of alkaloid chemistry has been reviewed with the exception of the steroidal alkaloids of the Solarium and Veratrum groups. It has not proved possible owing to limitations of space to include these sub-groups in the present volume, and it is therefore planned to include a review of developments in this area during a two-year period in the second volume. 

The intent of this chapter is to provide an update of pyridine and piperidine alkaloid literature since this topic was last covered in Volume 3 of this series [1], The approximate time period covered by this review is 1984-1994. Due to the wealth of information available, this review had to be somewhat selective. For example, with the exception of a few selected pyridine monoterpenes, alkaloids containing a pyridine or piperidine ring fused to another ring system were excluded. The focus of this review is placed on describing new compounds isolated, biosynthesis, and biological properties. Synthesis has not been emphasized in most cases reference is made to only the most recent syntheses. 

This second volume, which reviews the alkaloid literature from July 1970 to June 1971, approaches more closely the standard Specialist Periodical Report originally envisaged by the Chemical Society and adopts a form which, with minor variations, will very probably be followed in subsequent volumes. Once again the whole field of alkaloid chemistry has been reviewed, with the exception of the Steroidal Alkaloids of the Solanum and Veratrum Groups. The omission of these groups in the first volume was deliberate their inclusion in the second volume was intended, but proved to be impracticable, and we hope to remedy this omission in the third volume. It is fortunate, however, that this particular area can quite properly be discussed in a volume devoted to alkaloids or in one devoted to steroids and for a brief review of recent developments in this subject the reader is meanwhile referred to the Specialist Periodical Report on Terpenoids and Steroids, Volume One (Senior Reporter Dr. K. H. Overton). 

Although reference to individual securinine alkaloids have been made in previous volumes of this treatise (Vol. VII, XIII) and the literature dealing with work since 1969 has been summarized (9), no comprehensive review on this subject has appeared. It is the purpose of this contribution to fill this gap in the alkaloid literature. Coverage is complete through March 6, 1972 Chemical Abstracts. 

The proliferation of alkaloid literature which has been so marked for several decades has continued. The discovery of new sources of known alkaloids and the discovery of new alkaloids in new and already examined sources together with new structural and synthetic studies call for periodic reviews. This volume is an attempt to bring some of the alkaloid chemistry up-to-date. As in the more recent volumes we have chosen a number of subjects which seem appropriate at this time. 

Once again an annual review of the alkaloid literature is provided and this time there is a two-year coverage of Lycopodium Alkaloids. In an effort to cope with rising costs of production this Volum.e has been produced from camera-ready copy and I am grateful to the authors for their willing co-operation. 

A useful compendium of data on isoquinoline alkaloids has been published, this second volume bringing literature coverage in the series up to 1972. An introductory section deals with recent structure determinations, syntheses, and biogenetic correlations. A more general compilation includes new alkaloids described in 1973. The structure and absorption spectroscopy of steroids and alkaloids are the subject of another volume. Outstanding items in alkaloid literature during 1973 have been summarized. ... 

This second volume, published in March 1972. covers the alkaloid literature of the period July 1970-June 1971. The whole field of alkaloid chemistry, with the exception of certain steroidal alkaloids, is critically reviewed. 293pp 7-50 (Stillavailable. Vol. 1 SOSpp 3 / 00)... 

The policy adopted in this ninth volume of The Alkaloids is once again to furnish a comprehensive annual survey of the alkaloid literature. As a result of unavoidable omissions in the eighth volume, a two-year coverage is provided of tropane alkaloids and, within the isoquinoline group (Chapter 8), of the chemistry of emetine and related bases, dibenzopyrrocolines, benzophenanthridines, and colchicine. The chapter on Miscellaneous Alkaloids also surveys the literature of the period July 1976— June 1978 purines are no longer included. 

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