Alcohol inflammation limit

The limits of inflammation of organic substances, such as ether, alcohol, and acetone, in air have been determined by White and Price, Trans Ghent Soc., 1919, 115, 1462. 

At the end of the eighteenth and the beginning of the nineteenth century the influence of metals and oxides on the decomposition of several substances was studied by many scientists. It was noticed that contact with different substances gives very different products. An example is the decomposition of alcohol in the presence of copper or iron, carbon and an inflammable gas is produced. In the presence of pumice stone decomposition into ethene and water was observed. In other words, selectivity was demonstrated. Many other important milestones can be mentioned we limit ourselves to a few. Thenard investigated the dissociation of ammonia in contact with metals. In 1813 he found that the dissociation occurs over various metals, provided they are hot. Later he systematically studied the dissociation of hydrogen peroxide. He concluded that some of the solids studied... 

In hypergolic pairs of rocket propellants (- Hypergoiic), a delay in inflammation is understood to mean the time which elapses from the moment of contact between the reaction partners up to the initiation this delay is of the order of a few milliseconds, and must not exceed a certain limiting value thus, e.g. the inflammation delay of the reagent pair furfuryl alcohol - nitric acid is about 20 milliseconds. 

The peroxisome catalase system catalyses the hydrogen peroxide (H2O2 (-dependent oxidation of ethanol to acetaldehyde and water. Normally it contributes little to the oxidation of alcohol because of the limited availability of hydrogen peroxide. However, activation of peroxisomal catalase, by the increased generation of hydrogen peroxide via peroxisomal /3-oxidation, leads to an increased metabolism of alcohol. This state may contribute to an alcohol-related inflammation and necrosis in alcoholic liver disease. 

Elevated liver enzymes may occur in up to 15% of patients cirrhosis is rare. Liver function tests, aspartate aminotransferase (AST) or alanine aminotransferase (ALT), should be performed periodically. Methotrexate should be discontinued if these test values show sustained results greater than twice the upper limits of normal. Serum albumin levels also should be checked periodically, as signs of liver toxicity in some patients may not have liver inflammation manifested by AST or ALT elevation. Liver biopsy is now recommended before beginning methotrexate therapy only for patients with a history of excessive alcohol use, ongoing hepatitis B or C infection, or recurring elevation of AST. Biopsies during methotrexate therapy are recommended only for patients who develop consistently abnormal liver function tests. ... 

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