Alcohol condensation reactions with

Reaction of dibenzylamine with ethylene oxide affords the amino alcohol, 82. Treatment of that product with thionyl chloride gives the a-sympathetic blocking agent, dibenamine (83). (Condensation of phenol with propylene chlorohydrin (84) gives the alcohol, 85. Reaction with thionyl chloride affords the chloride (86). Use of the halide to alkylate ethanolamine affords the secondary amine (87). Alkylation of this last with benzyl chloride... 

Finally, a new water-soluble polyphosphazene was recently synthesized that has the structure shown in 36 (46). This polymer has two attributes as a biomedical macromolecule. First, the pendent carboxylic acid groups are potential sites for condensation reactions with amines, alcohols, phenols, or other carboxylic acid units to generate amide, ester, or anhydride links to polypeptides or bioactive small molecules. Second, polymer forms ionic crosslinks when brought into contact with di- or trivalent cations such as Ca or Ai3+. The crosslinking process converts the water-soluble polymer to a hydrogel, a process that can be reversed when the system... 

Dithiophosphoric and dithiophosphinic acids are strong acids, with pKa values typically in the range 1-2 (in water or alcohol solutions).1 Dithiophosphinic acids are predominately thermally unstable compounds, and tend to undergo a condensation reaction with elimination of H2S on storage at room temperature (Equation 21). Although dithiophosphoric acids can also undergo a similar decomposition reaction, higher temperatures are usually required (>120°C). 

Short-chain carboxylic acids are quite soluble in water and tend to ionize slightly (typically, a few percent depending on concentration). These acids undergo the typical acid-base reactions. Besides the condensation reaction with alcohols, acids condense with ammonia or amines to form amides. 

Pyrrole can be condensed under alkaline conditions with formaldehyde to give products of either N- or C-hydroxymethylation (Scheme 56). Benzo[ ]furan gives an isolable alcohol on reaction with glyoxylate using Y (OTf)3 as catalyst where attack has taken place at C(3) <2000JOC4732>. 

Similarly, urea TV, 0-acetal 64 undergoes condensation reaction with weak carbon acids to afford acyclic 1,1-enediamines with the elimination of alcohol and amine42,95. A number of active methyl compounds such as an aliphatic ketone, acetophenone, imino ester and thioacetoamide has been successfully converted to 1,1-enediamines. Lactones, lactams and thiolactams condense with 64 to give enediamines 65 in moderate yields (equation 24). Very weakly activated methyl groups are also reactive towards urea A, 0-acetal 64, and 1,1-enediamines 66-71 are prepared from the corresponding reactants42,95. 

This reaction leads to new deoxycellulose derivatives that contain a residue of acetylenic alcohol. Like the reactions on addition of water, methanol, or diethylamiiK, the condensation reaction with acetoiK proceeds quantitatively. 

SILIBOND CONDENSED (78-10-4) Forms explosive mixture with air (flash point 99°F/37°C). Reacts slowly with water, forming ethyl alcohol. Violent reaction with strong oxidizers. Incompatible with strong acids, nitrates. Attacks some plastics and rubber. 

Neither substance catalyzes hydrogen disproportionation reaction of cycloolefins. An essential difference was found in the action of these catalysts on alcohols. In the presence of vanadia, alcohols are hydro-genolyzed to the corresponding paraffins. At comparable conditions in the presence of chromia, alcohols undergo a dehydrogenation-condensation reaction with production of ketones. 

EXPLOSION and FIRE CONCERNS highly flammable liquid NFPA rating Health 2, Flammability 4, Reactivity 2 oxidizes readily in air to unstable peroxides that may explode spontaneously condensation reaction with acid anhydrides, alcohols, ketones, and phenols can be violent combination with bromine, chlorine, fluorine, or iodine can be violent reaction of anhydrous ammonia, hydrogen cyanide, or hydrogen sulfide can be violent use carbon dioxide, dry chemical powder, or appropriate foam for firefighting purposes. 

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