Alcohol analogues structure

In addition, Pfizer has identified a number of related, fused bicyclic pyrazole analogues [286-292]. These compounds, of which structures (419 25) are specified examples, are claimed to be of use in the treatment of a number of diseases including alcoholism, psychosis, tobacco abuse, Parkinson s disease and obesity. 

Sulphosuccinates are of particular interest not only for their technical properties but also because structurally they combine the two hydrophile functions described earlier - the sulphonate and carboxylate moieties - in a single molecule (9.18). The sulphosuccinate diesters, however, are probably of greater commercial importance in textile processing than are the monoesters. The most important example is sodium dioctylsulphosuccinate (9.19), but the dinonyl, dimethylamyl and di-isobutyl analogues are also used commercially. As usual, a wide choice of hydrophobes is available and includes alcohols, lightly ethoxylated alcohols, alkanolamides and combinations of these. 

L — maltolate the coordination environment of the vanadium in K[V02(malt)2] H2O is approximately octahedral, the two 0x0 ligands being in cis positions. [K(H20)e] units link adjacent vanadium(V) complex anions to give a chain structure 166). The main products of aerobic oxidation of [V O(dmpp)2l in aqueous solution are [V02(dmpp)] and [VOo(dmpp)2]. High pH favors these V products, whereas at low pH V species predominate 171). Vanadium(V) also forms a VO(OR)(malt)2 series, readily prepared from ammonium vanadate, maltol, and the appropriate alcohol in a water-alcohol-dichloromethane medium 172), and 3-hydroxy-4-pyridinonate analogues V0(0R)L2 on oxidation of their oxovanadium(IV) precursors in solution in the appropriate alcohol ROH 168). 

Native monellin consists of two polypeptide chains, a 45-residue A-chain and a 50-residue B-chain, linked by non-covalent interactions. At neutral pH, it is fairly resistant to heat denaturation with a higher than 80 °C. The crystal structure of native monellin shows a tertiary structure comprising an anti-parallel /1-sheet with five strands and an a-helix. H NMR spectroscopy and hydrogen exchange methods have been used to characterize the alcohol-denaturated state of monellin in order to understand how its secondary structure depends on environmental conditions. " Structural and dynamic studies by NMR have been carried out in order to compare native monellin and a non-sweet analogue in which Asp was replaced by Abu . The three-dimensional structures of the two proteins are found to be very... 

A large number of reports have concerned transfer hydrogenation using isopropanol as donor, with imines, carbonyls-and occasionally alkenes-as substrate (Scheme 3.17). In some early studies conducted by Nolan and coworkers [36], NHC analogues of Crabtree catalysts, [Ir(cod)(py)(L)]PF,5 (L= Imes, Ipr, Icy) all proved to be active. The series of chelating iridium(III) carbene complexes shown in Scheme 3.5 (upper structure) proved to be accessible via a simple synthesis and catalytically active for hydrogen transfer from alcohols to ketones and imines. Unexpectedly, iridium was more active than the corresponding Rh complexes, but... 

F]Fluorobenzophenones are also precursors, after reduction into the corresponding alcohol, of different complex structures such as a 5-HT2A receptor ligand [180] and several dopamine transporter ligands GBR 13119 [181], GBR 12909 [182] and analogues [183], NNC 12-0817 and 12-0818 [184] (Scheme 40). 

Catalytic activities of [Ru PW (H30)(0)3, ] -/03/CH3CN/80°C and of [Ru PMOjj(H30)(0)3, ] "/03/CH3CN were compared. The tungsten complex did not catalyse the aerobic oxidation of cumene and 1-octene to cumyl alcohol and 1-octene oxide while the Mo analogue did so the tungsten complex underwent structural change with to an inert form, while its molybdenum analogue did not... 

There has been recent interest in lanthanide complexes of ligands of the type (21). These are in some sense nitrogen analogues of the crown ethers. As Schiff bases, their lanthanide complexes may be synthesized by a template condensation, for example from 2,6-diacetylpyridine, 1,2-diaminoethane and lanthanum nitrate. These components react in alcohols to give [La(N03)3L], where the aza-crown L = (21 R = Me). This compound has a structure (Figure 6), quite analogous to that of [La(N03)3(18-crown-6)], in which La—N... 

Several crystal structures of the enzyme in the presence of the coenzyme and substrate or substrate analogues have served as important indicators of the role of the coenzyme in the enzymic reaction. A crystal structure of the enzyme in the presence of NAD+ and p-bromobenzyl alcohol as substrate revealed that the oxygen of the alcohol is directly bound to the catalytic zinc, thus putting the carbon 1 of the alcohol 3.5 A from carbon 4 of the nicotinamide ring the substrate is thus positioned ideally for direct transfer of hydrogen. The position of the alcohol is close to where the water molecule is bound in the free enzyme, but it was not possible to establish whether this had been displaced on binding of the substrate.1364... 

The structure of the reactive ternary complex composed of the enzyme NAD+, and 4-bromobenzyl alcohol was solved at 2.9-A resolution.14 This was possible because there is a favorable equilibrium between this complex and the enzyme-bound ternary complex reaction product of NADH and 4-bromo-benzaldehyde. The structure of the unreactive product-like complex composed of the enzyme, the coenzyme analogue H2NADH (i.e., NAD+ in which the nicotinamide ring has been reduced to 1,4,5,6-tetrahydronicotinamide), and trans-4- (N, A-dimethylamino)-cinnamaldehyde (DACA) was also solved at the same resolution.18... 

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