Aging successful

Leveille SG, Guralnik JM, Ferrucci L et al. (1999) Aging successfully until death in old age opportunities for increasing active life expectancy. Am J Epidemiol 149, 654-664. 

In work by Evans and co-workers, deprotection of a silyl ether with AgF leads to the formation of an intermediate positioned to undergo a rapid Cope rearrangement. Subsequent loss of methanol results in the formation of the deoxylapachol product in 95% yield (eq 12). Additionally, certain nitrosoalkenes, which can be active dienes in [4 + 2] cycloadditions, can be prepared from a-chlorosilyloximes by 1,4-elimination in the presence of an appropriate fluoride source, such as AgE Successful cycloadditions are also observed with cesium fluoride and potassium fluoride (eq 13). 

Ligos, Melinda. Incentives for the Ages. Successful Meetings. May 1998, pp. 49-54. 

In the Ability Age, successful research scientists in industrial laboratories have the ability to not only complete projects one at a time, but invent and apply emerging science and technologies to continually provide leading global valued growth at each step of a project. 

The preceding treatment relates primarily to flocculation rates, while the irreversible aging of emulsions involves the coalescence of droplets, the prelude to which is the thinning of the liquid film separating the droplets. Similar theories were developed by Spielman [54] and by Honig and co-workers [55], which added hydrodynamic considerations to basic DLVO theory. A successful experimental test of these equations was made by Bernstein and co-workers [56] (see also Ref. 57). Coalescence leads eventually to separation of bulk oil phase, and a practical measure of emulsion stability is the rate of increase of the volume of this phase, V, as a function of time. A useful equation is... 

I ew Rubber-Modified Styrene Copolymers. Rubber modification of styrene copolymers other than HIPS and ABS has been useful for specialty purposes. Transparency has been achieved with the use of methyl methacrylate as a comonomer styrene—methyl methacrylate copolymers have been successfully modified with mbber. Improved weatherability is achieved by modifying SAN copolymers with saturated, aging-resistant elastomers (88). 

The success of thrombus lysis depends mainly on how large the thrombus is and whether any blood flow stiU remains. The outcome is better the larger the surface of the entire thrombus exposed to the thrombolytic agent. As the clot ages, the polymerization of fibria cross-linking and other blood materials iacreases and it becomes more resistant to lysis. Therefore, the eadier the thrombolysis therapy starts, the higher the frequency of clot dissolution. Thrombolytic agents available are Hsted ia Table 7 (261—276). 

The commercial success of ABS polymers has led to the investigation of many other polyblend materials. In some cases properties are exhibited which are superior to those of ABS and some of the materials are commercially available. For example, the opacity of ABS has led to the development of blends in which the glassy phase is modified to give transparent polymers whilst the limited light aging has been countered by the use of rubbers other than polybutadiene. 

The sequence just outlined provides a salutary lesson in the nature of explanation in materials science. At first the process was a pure mystery. Then the relationship to the shape of the solid-solubility curve was uncovered that was a partial explanation. Next it was found that the microstructural process that leads to age-hardening involves a succession of intermediate phases, none of them in equilibrium (a very common situation in materials science as we now know). An understanding of how these intermediate phases interact with dislocations was a further stage in explanation. Then came an nnderstanding of the shape of the GP zones (planar in some alloys, globniar in others). Next, the kinetics of the hardening needed to be... 

This information comes from a quite remarkable book. Crystal Fire The Birth of the Information Age (Riordan and Hoddeson 1997), which maps out systematically but very accessibly the events that led to the discovery of the transistor and the aftermath of that episode. I know of no better aceount of the interloeking sequence of events that led to eventual success, and of the personal characteristics of the principal participants that played such a great part in the story. 

The electrical age was built on the discovery in the early 1830s, independently by Joseph Henry (1797-1878) in America and Michael Faraday (1791-1867) in England, of electromagnetic induction, which led directly to the invention of the dynamo to generate electricity from steam-powered rotation. It came to fruition on New Year s Eve, 1879, when Thomas Edison (1847-1931) in rural New Jersey, after systematic and exhaustive experiments, made the first successful incandescent lamp, employing a carbonised filament made from some thread taken from Mrs. Edison s sewing cabinet. The lamp burned undimmed for 40 h, watched anxiously by Edison and some of his numerous collaborators. This lamp was ideal for... 

During World War II, polychloroprene was chosen as a replacement for natural rubber because of its availability. Two copolymers of chloroprene and sulphur which contain thiuram disulphide were available (Neoprene GN and CG). One of the first successful applications of these polychloroprene adhesives was for temporary and permanent sole attachment in the shoe industry. However, these polychloroprene cements show a decrease in viscosity on ageing and a black discolouration appears during storage in steel drums. Discolouration was produced by trace amounts of hydrochloric acid produced by oxidation of polychloroprene... 

The spectacular success (in 1807) of Humphry Davy, then aged 29 y, in isolating metallic potassium by electrolysis of molten caustic potash (KOH) is too well known to need repeating in detail." Globules of molten sodium were similarly prepared by him a few days later from molten caustic soda. Earlier experiments with aqueous solutions had been unsuccessful because of the great reactivity of these new elements. The names chosen by Davy reflect the sources of the elements. 

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