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Aging protein glycosylation

Kirstein, M., Brett, J., RadoflT, S., Ogawa, S., Stem, D. and Vlassara, H. (1990). Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth fector role in vascular disease of diabetes and aging. Proc. Natl Acad. Sci. USA 87, 9010-9014. [Pg.196]

Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med 1995 46 223-234. [Pg.225]

Hunt, J.V., Dean, R.T. and Wolff, S. (1988). Hydroxyl radical production and autoxidative glycosylation. Glucose oxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. Biochem. J. 256, 205-212. [Pg.50]

The reaction between glucose and protein in the blood produces advanced glycosylation end-products (AGEs), which are metabolized in the proximal tubules. Hyperglycemia increases the synthesis of AGEs in patients with diabetes and the corresponding increase in metabolism is suspected to be a cause of nephropathy associated with diabetes.12... [Pg.376]

With time, the increased glucose concentration leads to glycosylation of the proteins over Amadori products to advanced glycosylation products (AGEs) and cross-linking between proteins. This degenerative process leads to the so-called late diabetic complications (LDC) after some decades. The four main complications are ... [Pg.143]

Although there is little question that glycosylated proteins increase with age, there is no direct evidence that they affect the life span. Nevertheless, this important area needs further study in order to more fully understand its effects on aging and disease. [Pg.6]

During the period of aging, posttranslational modified proteins and advanced glycosylation end products, which accumulate in tissues, might chronically stimulate HSP production, and affect the basal synthesis of this cell defense mechanism. In this regard, acutely induced HSP synthesis does decrease with aging. However, since the effect of age on the basal expression of HSP70 had not previously been addressed, Maiello and associates (M3) studied the age-dependent basal... [Pg.24]

Although glycosylated proteins increase significantly with age, are they primarily involved in aging and age-related diseases or are they merely biochemical markers of aging and have no primary role in the aging process Future studies should resolve this important question. [Pg.49]

P6. Patrick, J. S., Thorpe, S. R., and Baynes, J. W., Nonenzymatic glycosylation of protein does not increase with age in normal human lenses. J. Gerontol. 45, B18-B23 (1990). [Pg.56]


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See also in sourсe #XX -- [ Pg.5 ]




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