Advanced glycosylation end products

Brownlee, M., Cerami, A. and Vlassara, H. (1988). Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 318, 1315-1321. 

The reaction between glucose and protein in the blood produces advanced glycosylation end-products (AGEs), which are metabolized in the proximal tubules. Hyperglycemia increases the synthesis of AGEs in patients with diabetes and the corresponding increase in metabolism is suspected to be a cause of nephropathy associated with diabetes.12... 

Ding Q, Keller JN. 2005b. Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain. Neurosci Lett 373(1) 67—72. 

Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, Elliston K, Stern D, Shaw A. 1992. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 267(21) 14998-15004. 

Vissing H, Aagaard L, Tommerup N, Boel E. 1994. Localization of die human gene for advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3. Genomics 24(3) 606-608. 

During the period of aging, posttranslational modified proteins and advanced glycosylation end products, which accumulate in tissues, might chronically stimulate HSP production, and affect the basal synthesis of this cell defense mechanism. In this regard, acutely induced HSP synthesis does decrease with aging. However, since the effect of age on the basal expression of HSP70 had not previously been addressed, Maiello and associates (M3) studied the age-dependent basal... 

A. M. Schmidt, M. Vianna, M. Gerlach, J. Brett, J. Ryan, J. Kao, et d. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chetn, 267, (21), 14987 14997, 1992. Also M. Neeper, A. M. Schmidt,... 

Advanced glycosylated end products Parathyroid hormone Oxidation products... 

Radoff S, Makita Z, Vlassara H. Radioreceptor assay for advanced glycosylation end products. Diabetes 1991 40 1731-8. 

The Amadori sugar-amino acid residue adducts in proteins are produced with prolonged hyperglycemia and undergo progressive nonenzymatic reactions involving dehydration, condensation, and cyclization. These compounds are collectively known as advanced glycosylation end products and are involved in the chronic complications of diabetes mellitus (cataracts and nephropathy) (Chapter 22). 

H. Vlassara Recent progress on the biological and clinical significance of advanced glycosylation end products. J. of Laboratory arui Clinical Medicine, 124, 19 (1994). 

V7. Vlassara, H., Brownlee, M., and Cerami, A., Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation end products. /. Exp. Med. 160, 197-207 (1984). 

Vlassara H, Fuh H, Makita Z, Krungkrai S, Cerami A, Bucala R. Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals A model for diabetic and aging comphcations. Proc Natl Acad Sci USA 1992 89 12043-12047. 

Edelstein D, Brownlee M. Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine. Diabetes 1992 41 26-29. 

Lin CH, Lin YF, Chang MC, Wu CH, Ho YS, Lee HM (2001) Advanced glycosylation end products induce nitric oxide synthase expression in C6 glioma cells involvement of a p38 MAP kinase-dependent mechanism. Life Sci 69 2503-2515... 

Makita Z, Radoff S, Rayfield EJ, Yang Z, Skolnik E, Delaney V, Friedman EA, Certuni A Vlassara H. (1991). Advanced glycosylation end products in patients with diabetic nephropathy. N Engl J Med 325, 836-842. 

F. G. Njoroge, A. A. Fernandes and V. M. Monnier, Mechanism of formation of the putative advanced glycosylation end product and protein cross-link 2-(2-furoyl)-4(5)-(2-furanyl)-lH-imidazole, /. Biol Chem., 1988,... 

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