Aging population, heterogeneity

The unstructured and segregated model considers the cell culture as a heterogeneous population, with individual cells characterized by age, mass, or size. The variation of properties follows a statistical distribution. The most concise way to deal with such population heterogeneity is through a population balance model (PBM). These models can become mathematically complex because the equations that describe the population have to consider that the properties vary in the population and... 

The most controversial approved use of GH is for children with idiopathic short stature, also known as non-growth-hormone-deficient short stature. This is a heterogeneous population that is defined clinically by a height that is 2.25 standard deviations or more below the national norm for children of the same age. Eligible children also have growth... 

Based on the substantive heterogeneity of the elderly population, a recent strategy groups the aging processes into three possible trajectories, thereby challenging the inevitability of functional impairment with aging911 ... 

One problem encountered when assessing exposure of human populations to contaminated land is spatial heterogeneity of pollution. To overcome this problem, Gay and Korre (2006) propose the combinations of spatial statistical methods for mapping soil concentrations, and probabilistic human health risk assessment methods. They applied geostatistical methods to map As concentrations in soil. Subsequently, an age-stratified human population was mapped across the contaminated area, and the intake of As by individuals was calculated using a modified version of the Contaminated Land Exposure Assessment (CLEA) model. This approach allowed a... 

Threshold relationships will tend to be smoothed when applied to a strongly heterogeneous population the response may depend strongly on e.g. age, gender, genetic constitution and health status. 

The word geriatric refers to individuals who are over age 65 years. This has been described as the most heterogeneous population because it constitutes fit, physiologically healthy patients to extremely frail, debilitated patients in long-term care facilities (LTCF). 

The heterogeneity of study design among the studies can be treated as a random effect and is ignored unless the studied population differs from the population to be analyzed (e.g., in age and/or renaFhepatic function). For studies where the... 

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