Adverse drug reactions metabolic

Kalgutkar, A.S., Obach, R.S. and Maurer, T.S. (2007) Mechanism-based inactivation of cytochrome P450 enzymes chemical mechanisms, structure-activily relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Current Drug Metabolism, 8, 407—447. 

Age-related changes in phase I metabolism coupled with the use of multiple medications place older patients at increased risk for adverse drug reactions. Adverse drug reactions occur due to either inhibition or induction of CYP enzymes, especially CYP3A, which is believed to be involved in the metabolism of more than one half of the currently prescribed drugs.Clinical outcomes are determined by... 

Metabolic Enzyme" Genetic Variation (Alleles) Frequency of Genetic Variant [% and (Race )] Functional Consequence [% Frequency (Race ) in Population] Drug Substrate Implicated in Adverse Drug Reactions... 

Thiebaut R, Daucourt V, Malvy D. Lipodystrophy, glucose and lipid metabolism dysfunctions. Aquitaine Cohort. First International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, San Diego, 1999 Abstract 17. 

A Abe ACE ACh ADME ADR Ala Arg Asp ATP dATP AUC Adenine Abequose Angiotensin-converting enzyme Acetyl choline Absorption, distribution, metabolism and elimination Adverse drug reaction Alanine Arginine Aspartate Deoxyadenosine triphosphate Adenosine triphosphate Area under the curve... 

The area under the curve of pantoprazole plasma concentration versus time (AUC) for a slow metabolizer is generally approximately 5 times higher than that for an average patient. Since pantoprazole is considered safe and well tolerated, and no dosage related adverse drug reactions have been identified, this finding seems to be of no clinical relevance. 

Isoniazid can cause neuropsychiatric syndromes, including euphoria, transient impairment of memory, separation of ideas and reality, loss of self-control, psychoses (421), and obsessive-compulsive neurosis (422). Isoniazid should be used with caution in patients with pre-existing psychoses, as it can cause relapse of paranoid schizophrenia (423). Patients on chronic dialysis appear to be vulnerable to neurological adverse drug reactions, because of abnormal metabolism of uremic toxins. It is therefore recommended that a... 

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