Idiosyncratic adverse drug reactions

Kalgutkar, A.S., Obach, R.S. and Maurer, T.S. (2007) Mechanism-based inactivation of cytochrome P450 enzymes chemical mechanisms, structure-activily relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Current Drug Metabolism, 8, 407—447. 

Ghajar BM, Naranjo CA, Shear NH, Lanctot KL. Improving the accuracy of the differential diagnosis of idiosyncratic adverse drug reactions (lADRs) skin eruptions and sulfonamides. CUn Pharmacol Ther 1990 47(2) 127. 

Familial Occurrence of Idiosyncratic Adverse Drug Reactions.479... 

Genetic Contribution to Idiosyncratic Adverse Drug Reactions. 480... 

Idiosyncratic adverse drug reactions can basically be divided into two categories (Pirmohamed et al. 1998) ... 

Fig. 1 The multigenic and multifactorial nature of idiosyncratic adverse drug reactions. The occurrence of an idiosyncratic reactions is dependent on the interaction between multiple genes and environmental factors...

Table 3 Consortia that have been formed to investigate the genetic basis of idiosyncratic adverse drug reactions...

In conclusion, there is increasing evidence to show that idiosyncratic adverse drug reactions are genetically determined. Identification of such factors is important, not... 

Uetrecht, J. and D.J. Naisbitt, Idiosyncratic adverse drug reactions current concepts. Pharmacol Rev, 2013. 65(2) p. 779-808. 

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