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Structure-activily relationship

Kalgutkar, A.S., Obach, R.S. and Maurer, T.S. (2007) Mechanism-based inactivation of cytochrome P450 enzymes chemical mechanisms, structure-activily relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Current Drug Metabolism, 8, 407—447. [Pg.192]

T. Liljefors, in Computer-Assisted Lead Finding and Optimization (Proceedings of the 11th European Symposium on Quantitative Structure-Activily Relationships, Lausanne 1996),... [Pg.66]

Lewis DF, Lake BG, Ito Y, Anzenbacher P (2006) Quantitative structure-activily relationships (QSARs) within cytochromes P450 2B subfamily enzymes the importance of lipophilicity for binding and metabolism. Drug Metab Drug Interact 21 213-231... [Pg.169]

Delaforge M, Jaouen M, Mansuy D (1983) Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes a structure-activily relationship. Biochem Pharmacol 32 2309 2318... [Pg.246]

Sulfated sterols have several types of biological activity, in particular antiviral activily, which has aheady been mentioned in relation to sponges (see Chapter 19). Studies of structure-activity relationships have established that the presence of sulfate groups on rings A and B contributes greatly to this activity, whereas their presence on ring D has no effect. The presence of sulfate groups on the side chain, in particular on carbon 21, induces only little activity... [Pg.726]

See other pages where Structure-activily relationship is mentioned: [Pg.486]    [Pg.522]    [Pg.486]    [Pg.522]    [Pg.959]   
See also in sourсe #XX -- [ Pg.348 , Pg.352 ]



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