Adverse drug reactions dermatological

American Academy of Dermatology Association of the British Pharmaceutical Industry Australian Competition and Consumer Commission Adverse Drug Reactions Advisory Committee... 

Lazarou J, Pomeranz BH, Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients a meta-analysis of prospective studies. JAMA 279 1200-1205 Lipper GM, Amdt KA, Dover JS (2000) Recent therapeutic advances in dermatology. JAMA 283 175-177... 

Jachiet M, Bellon N, Assier H, Amsler E, Gaouar H, Pecquet C, et al. Cutaneous adverse drug reaction to oral acetazolamide and skin tests. Dermatology 2013 226(4) 347-52. 

Cutaneous adverse reactions were reported to occur in 2.7% of hospitalized patients. Serious dermatologic drug reactions are estimated to occur in 1.9 cases per 1 million people per year and can have a mortality rate as high as 40%. Table 86-2 lists drugs and agents associated most commonly with cutaneous reactions. Antimicrobials are implicated most frequently with reaction rates ranging from 1 % to 8%. In a report of almost 6000 children, about 12% developed rashes with cefaclor compared with 7.4% with penicillins and 8.5% with sulfonamides. " ... 

The majority of adverse effects to sulfonamides are mild in nature and reversible, although idiosyncratic drug reactions may occur. Urinary tract disturbances, including sulfonamide crystalluria and hematuria, can be minimized in susceptible animals by maintaining an adequate water intake to maintain a high urine flow. Bone marrow depression and dermatologic reactions have also been associated with sulfonamide therapy in animals. 

Wilson C, Greenhood G, Remington JS (1979) Neutropenia after consecutive treatment courses with nafcillin and piperacillin. Lancet 1 1150 Wintroub BU, ShifFman NJ, Arndt KA (1979) Adverse cutaneous reactions to drugs. In Fitzpatrick TB (ed) Dermatology in general medicine, 2nd edn. McGraw-Hill, New York, p 555... 

Livedo reticularis sometimes occurs in patients taking amantadine and usually clears within 1 month after the drug is withdrawn. Other dermatologic reactions have also been described. Peripheral edema, another well-recognized complication, is not accompanied by signs of cardiac, hepatic, or renal disease and responds to diuretics. Other adverse reactions to amantadine include headache, heart failure, postural hypotension, urinary retention, and gastrointestinal disturbances (eg, anorexia, nausea, constipation, and dry mouth). 

Unithiol has been reported to have a low overall incidence of adverse effects (< 4%). Self-limited dermatologic reactions (drug exanthems or urticaria) are the most commonly reported adverse effects, although isolated cases of major allergic reactions, including erythema multiforme and Stevens-Johnson syndrome, have been reported. Because rapid intravenous infusion may cause vasodilation and hypotension, unithiol should be infused slowly over an interval of 15-20 minutes. 

Hogan, D.J. Maibach, H.I. Adverse dermatologic reactions to transdermal drug delivery systems. J. Am. Acad. Dermatol. 1990, 22 (5 Pt 1), 811-814. 

Dermatological adverse effects are not uncommon with griseofulvin and are of considerable variety. The following have been described urticaria (28,29), photosensitivity eruptions (30), erythema multiforme (31), morbilliform rashes (32), serum sickness-like reactions (33), fixed drug eruption (29,34,35), Stevens-Johnson syndrome (36), vasculitis (37), toxic epidermal necrolysis (38,39), and lupus erythematosus (40,41). 

Letendre PW, Barr C, Wilkens K. Adverse dermatologic reaction to transdermal nitroglycerin. Drug InteU Qin Pharm 1984 18(l) 69-70. 

De Groot AC, Frosch PJ (1997) Adverse reactions to fragrances. A clinical review. Contact Dermatitis 36 57-86 De Groot AC, Weyland JW, Nater JP (eds) (1994) Contact allergy to fragrance materials. In Unwanted effects of cosmetics and drugs used in dermatology, 3rd edn. Elsevier, Amsterdam, Chap. 5.8-5.15, pp 65-72... 

Reports of the non-antimicrobial effects of tetracyclines continue to appear, and the clinical uses of non-antimicrobial tetracyclines in dermatology have been highlighted [119 ]. In general, when these drugs are used for non-infectious conditions, adverse reactions seem to be of same types and frequencies as when they are used as antimicrobial agents. However, the adverse effects profiles of the chemically modified tetracyclines have still not been properly elucidated. 

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