Adult respiratory syndrome

Hypoglycemia, acute renal failure, pulmonary edema, severe anemia, thrombocytopenia, high-output heart failure, cerebral congestion, seizures and coma, and adult respiratory syndrome ... 

PA S1 S01.131 Neutrophil elastase Drug target for emphysema, cystic fibrosis, adult respiratory distress syndrome, rheumatoid arthritis and other diseases... 

In the past number of years a number of studies have shown that in a variety of diseases there is a significant oxidation of Met residues to Met(O) in specific proteins that results in a loss of biological activity. These diseases include cataracts, rheumatoid arthritis, adult respiratory distress syndrome and emphysema. The most convincing evidence that Met(O) in proteins may be involved in the etiology of a pathological condition comes from studies with a-l-PI. It is well accepted that a-l-PI is inactivated upon oxidation of its Met residues. A decreased activity of a-l-PI in lung tissue that would result in an increased elastase activity has been associated with pulmonary emphysema. In patients who have a... 

Quinlan, G.J., Evans, T.W. and Gutteridge, J.M.C. (1994). Linoleic acid and protein thiol changes suggestive of oxidative damage in the plasma of patients with adult respiratory distress syndrome. Free Bad. Res. Commun. 20, 299-306. 

Cross, C.E., Forte, T., Stocker, R., Louie, S., Yamamoto, Y., Ames, B.N. and Frei, B. (1990). Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. J. Lab. Clin. Med. 115, 396-404. 

MacNaugJiton, P.D. and Evans, T.W. (1992). Management of adult respiratory distress syndrome. Lancet 339, 469-472. 

Ognibene, F.P., Martin, S.E. and Parker, M.M. (1986). Adult respiratory distress syndrome in patients with severe neutropenia. N. Engl. J. Med. 315, 547-551. 

Dyspnea (31%), pulmonary edema, and adult respiratory distress syndrome... 

F7. Fink, A., Geva, D Zung, A., Konichezky, S., Eliraz, A., and Bentwich, Z., Adult respiratory distress syndrome Roles of leukotriene, C4 and platelet activating factor. Crit. Care Med. 18, 905-910(1990). 

J6. Jebsen, S., Herlevsen, P., Knudsen, P Bud, M. I and Klausen, N. O., Antioxidant treatment with A/-acetylcysteine during adult respiratory distress syndrome A prospective randomized, placebo-controlled study. Cril. Care Med. 20,918-923 (1992). 

L5. Leff, J. A., Parsons, P. E., and Day, C. E Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis. Lancet 341,777-780 (1993). 

P14. Pohl, W., Kindas-Mugge, J., Kohn, H., Fitzal, S Micksche, M., and Kummer, F., Elevated heat shock protein 72 expression by human alveolar macrophages during the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 147, A70(Abst) (1993). 

Damage to connective caused by leakage of elastases leads to damage associated with inflammatory diseases, such as pulmonary emphysema, adult respiratory distress syndrome, septic shock, cystic fibrosis, carcinogenesis, chronic bronchitis, and rheumatoid arthritis. Compounds that directly inhibit elastase or its release from human neutrophils are of enormous pharmaceutical and cosmetological interest in the development of new anti-inflammatory drugs. A possible source for elastase inhibitors are the medicinal Asteraceae and Droseraceae, particularly those used as traditional medicine in Asia. 

Suggested Alternatives for Differential Diagnosis Bronchitis, pneumonia, meningitis, gastroenteritis, septic shock, congestive heart failure and pulmonary edema, pleural effusion, costochondritis, prostatitis, adult respiratory distress syndrome (ARDS), HIV infection and AIDS, and Q fever. 

Commonly reported side effects include bone and muscle pain. Serious (sometimes life threatening) but rare side effects have included splenic rupture and adult respiratory distress syndrome. Neupogen is manufactured and marketed by Amgen Inc. 

Respiratory alkalosis secondary to hyperventilation is usually observed secondary to CNS stimulation of ventilatory centers as a result of trauma, sepsis, or shock. Lung auscultation may reveal crackles (pulmonary edema) or absence of breath sounds (pneumothorax, hemothorax). Chest roentgenogram can confirm early suspicions or disclose an undetected abnormality such as pneumonia (pulmonary infiltrates). Continued insult to the lungs may result in adult respiratory distress syndrome. 

Nguyen, L.T., Luong, K.V., and Pham, B.V., An antineutrophil cytoplasmic autoantibody associated with a propylthiouracil-induced adult respiratory distress-like syndrome Report of a case and review of the literature, Endocr. Pract., 4, 89, 1998. 

However, it is now recognised that neutrophils can contribute to host-tissue damage if they are activated to secrete reactive oxidants and granule enzymes, and if the local concentrations of anti-oxidants and protease inhibitors within the tissue are low or defective. Thus, inappropriate neutrophil activation leading to host-tissue damage has been implicated in reperfusion injury, Crohn s disease, adult respiratory distress syndrome (ARDS) and rheumatoid arthritis. In these conditions, it is envisaged that neutrophils accumulate in tissues and become inappropriately activated to secrete their cytotoxic products, which then initiate or contribute to host-tissue damage. 

Failure to synthesise sufficient surfactant or the synthesis of abnormal surfactant, so that surface tension cannot be lowered, may play a role in several conditions respiratory distress syndrome of the newborn sudden infant death ( cot death ) and adult respiratory distress syndrome. The enzymes involved in the synthesis of surfactant only appear during the third trimester of pregnancy, so that surfactant is not produced in premature babies and they have difficulty breathing. 

ARDS 2% of patients were reported to have adult respiratory distress syndrome (ARDS) during clinical studies. 

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