Splenic rupture

Commonly reported side effects include bone and muscle pain. Serious (sometimes life threatening) but rare side effects have included splenic rupture and adult respiratory distress syndrome. Neupogen is manufactured and marketed by Amgen Inc. 

Although the two growth factors have similar effects on neutrophil counts, G-CSF is used more frequently because it is better tolerated. G-CSF can cause bone pain, which clears when the drug is discontinued. GM-CSF can cause more severe side effects, particularly at higher doses. These include fevers, malaise, arthralgias, myalgias, and a capillary leak syndrome characterized by peripheral edema and pleural or pericardial effusions. Allergic reactions may occur but are infrequent. Splenic rupture is a rare but serious complication of the use of G-CSF for PBSC. 

Dancygier, H., Jacob, R.A. Splenic rupture during laparoscopy. Gastrointest. Endosc. 1983 29 63. 

Sandberg-Gertzen, H., Ericzon, B.G., Blomberg, B. Primary amyloidosis with spontaneous splenic rupture, cholestasis, and liver failure treated with emergency liver transplantation. Amer. J. Gastroenterol. 1998 93 2254-2256... 

Kasper C, Jones L, Fujita Y, Morgenstern GR, Scarffe JH, Chang J. Splenic rupture in a patient with acute myeloid leukemia undergoing peripheral blood stem cell transplantation. Ann Hematol 1999 78(2) 91-2. 

Daybell D, Paddock CD, Zaki SR, et al. Disseminated infection with Bartonella henselae as a cause of spontaneous splenic rupture. Clin Infect Dis. 2004 39 21-24. 

Plasmodium vivax> responsible for the most prevalent form of malaria (benign tertian), has an incubation period of 8—27 days (14 average). A variety seen in northern and northeastern Europe has an incubation period as long as 8—10 months. The disease can cause splenic rupture and anemia. Relapses (renewed manifestations of erythrocytic infection) can occur with this type of malaria. Overall, P. vivax is still susceptible to chloroquine however, resistant strains have been reported from Papua New Guinea and parts of Indonesia. Plasmodium malariae, the cause of quartan malaria, has an incubation period of 15—30 days and its asexual cycle is 72 hours. This mildest form of malaria can cause nephritis in addition to the usual symptoms. It is a nonrelapsing type of malaria but the red blood cell infection can last for many years. No resistance to chloroquine by this plasmodium has been reported. Plasmodium ovale, responsible for ovale tertian malaria, has an incubation period of 9—17 days (15 average). Relapses can occur in people infected with this plasmodium. No chloroquine resistance has been reported for this parasite. 

Pegfilgrastim Pegylated-GCSF Neutropenia Splenic rupture, respiratory distress... 

Athale UH, Kaste SC, Bodner SM, Ribeiro RC (2000) Splenic rupture in children with hematologic malignancies. Cancer 88 480-490... 

Gardner RV, Warrier RP, Loe W, Ward K, Haymon M, Graver R (2003) Splenic artery embolization as emergency treatment of splenic rupture in a child with T-cell acute lymphocytic leukemia having t(8 14) translocation. Med Pediatr Oncol 41 492-493... 

Fernandes L Rodrigues, dos Santos C Lares, Barata F, Costa F. Spontaneous splenic rupture in a patient with small-cell cancer. BMJ Case Reports 2013. http //dx.doi.org/10.1136/bcr-2013-010325. 

The force of the water stream may throw individuals violently to the ground or against nearby objects. It may be forceful enough to tear off clothing, cause fractures or theoretically blimt intra-abdominal injury, such as a splenic rupture. 

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