Adrenergic receptor localization

Palacios, J.M. and Kuhar, M.J. (1980) Beta-adrenergic-receptor localization by light microscopic autoradiography. Science 208 1378-1380. 

O Dowd, B. F., Hnatowich, M., Regan, J. W., Leader, W. M., Caron, M. G., and Lefkowitz, R. J. (1988). Site-directed mutagenesis of the cytoplasmic domains of the human / 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. / Biol. Chem. 263, 15985-15992. 

Eason MG, Liggett SB. Chimeric mutagenesis of putative G-protein coupling domains of the a2A-adrenergic receptor - Localization of two redundant and fully competent Gi coupling domains. J Biol Chem 1996 271 12,826—12,832. 

Toews ML, Prinster SC, Schulte NA. Regulation of a1B adrenergic receptor localization, trafficking, function, and stability. Life Sci 2003 74 379-389. 

Palacios JM, Kuhar MJ. 1982. Beta adrenergic receptor localization in rat brain by light microscopic autoradiography. Neurochem Int 4 473-490,... 

Both beta and alpha receptors are present in PC. In fact, both receptor types and their subunits are specifically localized in layer II of PC, while some studies see possible expression of the beta subtype in layer I (Nicholas et al. 1993 Wanaka et al. 1989 Sargent-Jones et al. 1985 Young and Kuhar, 1980a Palacios and Kuhar, 1982 Unner-stall et al. 1984). This pattern of adrenergic receptor localization suggests that noradrenergic terminals from the nucleus locus coeruleus make synaptic connectivity in this layer of PC. 

Lyon, A. R. Nikolaev, V. O. Miragoli, M. Sikkel, M. B. Paur, H. Benard, L. Hulot, J.-S. Kohlbrenner, E. Hajjar, R. J. Peters, N. S., Plasticity of surface structures and P2-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circulation Heart Failure 2012, 5, 357-365. 

Adrenergic receptor one of several classes of membrane-localized receptors that recognize adrenaline and noradrenaline as agonists. 

Aoki C, Go CG, Venkatesan C, Kurose H (1994) Perikaryal and synaptic localization of OjA-adrenergic receptor-like immunoreactivity. Brain Res 650 181-204 Arnsten AFT, Goldman-Rakic PS (1985) O Adrenergic mechanism in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230 1273-1376... 

Aoki, C., Go, C.G., Venkatesan, C., and Kurose, H. (1994) Perikar-yal and synaptic localization of (Xj -adrenergic receptor—like im-munoreactivity. Brain Res 650 181-204. 

Reznikoff GA, Manaker S, Rhodes H, et al Localization and quantification of (3-adrenergic receptors in human brain. Neurology 36 1067-1073, 1986... 

Posttranslational modification in the form of palmitoylation of the cytosolic domain (see 3.7.2) has been demonstrated for the a- and P-adrenergic receptor. The palmitoylation takes place on a Cys-residue localized at the C-terminus on the membrane iimer side. The modification may possibly serve to anchor the C-terminus in the membrane. 

Epinephrine (Adrenalin, Bronkaid Mist, Primatene Mist, others). Epinephrine appears to directly stimulate all adrenergic receptor subtypes and is administered for a variety of reasons. Epinephrine is found in many antiasthmatic inhalation products because of its ability to stimulate beta-2 receptors on the bronchi. Because it stimulates vascular alpha-1 receptors, epinephrine may be applied topically to produce local vasoconstriction and control bleeding during minor surgical procedures (e.g., suturing superficial wounds). Likewise, epinephrine may be mixed with a local anes-... 

S. A. Green, A. P. Spasoff, R. A. Coleman, M. Johnson, and S. B. Liggett, Sustained activation of a G protein-coupled receptor via anchored agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor, J. Biol. Chem. 277 24029 (1996). 

Aoki C, Go CG, Venkatesan C, Kurose H. 1994. Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity. Brain Res 650 181-204. 

---