Adrenergic blocker

Among the indole derivatives which have found use as drugs are indo-methacin, one of the first non-steroidal anti-inflammatory agentsfll], sumatriptan, which is used in the treatment of migraine headaches[12] and pindolol[13], one of the p-adrenergic blockers. 

Synthetic Derivatives of Indoles as Pharmaceuticals. Thousands of indole derivatives have been prepared and evaluated as potential pharmaceuticals (32). Of those which have been put into use perhaps the most important are the nonsteroidal antiinflammatory agent indomethacin [53-86-1] (10) (33) and the p-adrenergic blocker pindolol [13823-86-9] (11) (34). 

Propranalol hydrochloride (5-l-isopropylamino-3-(l-naphthyloxy)-2-propanol HCl) [4199-10-4] M 295.8, m 192°, 193-195 , [a] +25° (c 1, EtOH) pK 9.5. See preceding entry for physical properties. The is the active isomer which blocks isoprenaline tachycardia and is a (i-adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 7987 Howe and Shanks Nature 210 1336 7966.]... 

Various bioisosteric replacements for a phenolic hydroxyl have been explored. One such, a lactam NH, is incorporated into the design of the 3-adrenergic blocker, carteolol O)- The fundamental synthon is carbostyril derivative K This is reacted in the usual manner with epichlorohydrin to give which is in turn reacted with t-butylamine to complete the synthesis of carteolol (3 ), a drug that appears to have relatively reduced nonspecific myocardial depressant action. Carrying this de-... 

The ergolines have provided a number of drugs that show interaction with neurotransmitters. Depending on the substitution pattern, they may be dopamine agonists or antagonists, a-adrenergic blockers, or Inhibitors of the release of prolactin. A recent member of the series, pergolide... 

Observe caution while driving or performing other hazardous tasks because these drugp ((3-adrenergic blockers) may cause drowsiness, dizziness, or light-headedness. 

Glucagon. In patients taking (3-adrenergic blockers, the response to epinephrine is impaired. Glucagon may reverse this effect and should be given to those patients [57]. 

Rarely, patients are refractory to epinephrine treatment [24], and require other potent vasopressors [1, 2, 18, 22]. In those patients who are refractory to epinephrine because they are taking a (J-adrenergic blocker, glucagon should be administered intravenously [5, 18]. 

Sharpless used asymmetric epoxidation as the crucial method in the preparation of the p-Adrenergic blocker, (S)- propanolol (Eqn. (26)). 

Consider glucagon 2-10 mg IV bolus followed by a 2-10 mg/h continuous IV infusion in P-adrenergic blocker or calcium channel blocker-induced bradycardia not responsive to atropine... 

Sotalol Sotalol Avoid Adenosine P-adrenergic blockers Calcium channel blockers Digoxin... 

Hypotension and bradycardia may be seen if combined with a P-adrenergic blocker... 

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