Dopamine Adrenergic neurone blockers

Conventionally called adrenergic neuron blockers, the last group of adrenoblockers are drugs that suppress synthesis, storage, and release of biogenic amines (norepinephrine, dopamine, or serotonin) in nerve endings. 

Adrenergic neuron blockers cause degradation of biogenic amines in neuron endings. These drugs can interfere with the synthesis, storage and release of norepinephrine, dopamine, and serotonin. 

First, the extracts of the roots of Ruscus aculeatus at higher concentrations caused their contractions of canine cutaneous veins in part because the extracts could reveal an indirect sympathomimetic effect for the inhibition to the neuronal uptake such as cocaine (40) (Figure 11) of a serotonin-norepinephrine-dopamine reuptake inhibitor [31]. Here, a selective ai-adrenergic blocker prazosin (41) and a selective a2-adrenergic blocker rauwolscine (a-yohimbine. 42) (Figure 11) are present in the canine saphenous vein [32, 33] might greatly contribute to their contractile response to the extracts of the roots of Ruscus aculeatus. 

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