Adolescent inflammatory bowel disease

Reniers DE, Howard JM. Isotretinoin-induced inflammatory bowel disease in an adolescent. Ann Pharmacother 2001 35(10) 1214-16. 

Other Conditions. Other groups of individuals are considered to be at risk either from a marginal dietary deficiency or from an acquired deficiency secondary to disease. These groups would include female adolescents during pregnancy and lactation. Also affected may be patients with malabsorption syndrome, inflammatory bowel disease, alcoholic liver disease, and anorexia nervosa. A significant proportion of cases of sickle cell anemia have clinical signs and symptoms and some laboratory abnormalities of zinc deficiency. These patients respond well to zinc supplementation. ... 

Ohtsuka Y, Arai K, Aoyagi Y, Fujii T, Yamakawa Y, Ohtani K, Ikuse T, Baba Y, Inage E, Kudo T, Suzuki R, Nagata S, Shimizu T. Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease. J Gastroenterol Hepatol 2010 25(10) 1626-30. 

Susceptibility factors Inflammatory bowel disease is a susceptibility factor for abnormal bone metabolism, with a large amount of evidence of increased incidences of osteopenia and osteoporosis in adults. However, only a few studies of bone mineral density have been performed in children and adolescents with inflammatory bowel disease. Bone mineral density in the lumbar spine has been evaluated in 40 children and adolescents with inflammatory bowel disease, mean age 12 years, 26 with ulcerative colitis and 14 with Crohn s disease, in order to identify the associated susceptibility factors [15 ]. There was a low bone mineral density (Z-score worse than —2) in 25% of patients, with equal prevalences in Crohn s disease and ulcerative cohtis. Height for age, basal metabolic index, and cumulative glucocorticoid dose had independent effects, and these effects remained significant after adjustment for disease duration. 

Lopes LH, Sdepanian VL, Szejnfeld VL, de Morais MB, Fagundes-Neto U. Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease. Dig Dis Sci 2008 53(10) 2746-53. 

Pappa HM, Mitchell PD, Jiang H, Kassiff S, Filip-Dhima R, EHFabio D, et al. Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease a randomized dinical trial comparing three regimens. J Clin Endocrinol Metab June 2012 97(6) 2134r-42. 

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