Adipogenesis, regulator

Adipocytes have an important secretory function. Numerous factors (collectively termed adipokines or adipocytokines), mostly peptides but also eicosanoids are produced by preadipocytes and mature adipocytes (Table 9.3). Some of these factors act in an autocrine or paracrine fashion to regulate adipogenesis, that is differentiation and maturation of adipocytes themselves, whilst others, notably, leptin, adiponectin and some cytokines act in truly endocrine way, having effects on the brain, endothelial cells, liver and skeletal muscle. Disturbance in secretion from adipocytes is associated with eating disorders and metabolic syndrome. 

Jeon, T., Hwang, S. G., Hirai, S., Matsui, T., Yano, H., Kawada, T., Lim, B. O., and Park, D. K. 2004. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci. 75(26), 3195-3203. 

Wahli, W., Braissant, O., and Desvergne, B. (1995). Peroxisome prolrferata- activated receptors transcriptional regulators of adipogenesis, lipid metabolism and more. Chem Biol 2, 261-266. 

In cultured cell lines, PPARy, which is expressed during the late stages of adipocyte differentiation, has been shown to be the master regulator of adipogenesis. Some of the... 

Other probable effects of co-3 fatty acids are membrane-mediated prcxosses, such as insulin transduction signals activity of lipases, which are affected by alteration of the fatty acid composition of the membrane phospholipids and regulation of genes involved in lipid and glucxrse metabolism, and adipogenesis. ... 

Katsumata, M., S. Kobayashi, M. Matsumoto, E. Tsuneishi and Y. Kaji, 2005. Reduced intake of dietary lysine promotes accumulation of intramuscular fat in the Longissimus dorsi muscle of finishing gilts. Anim. Sci. J. 76, 237-244. Mandrup, S. and M.D. Lane, 1997. Regulating adipogenesis. J. Biol. Chem. 272, 5367-5370. 

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