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Adhatoda

The alkaloid vasicine was first isolated from Adhatoda vasica in 1925 but the structure (996) was elucidated only after a great amount of work, culminating in two independent syntheses in 1935 (B-53MI21301). It was made subsequently by a simple route from 2-aminobenzaldehyde and 4-amino-2-hydroxybutyraldehyde (994) followed by dehydration of the tricyclic intermediate (995) (60TL(25)44>. Vasicine has bronchodilatory activity of a low order. Two related unnamed alkaloids (997) and (998) were obtained in 1965 from members of the Araliaceae family, viz. Mackinlaya subulata and M. macrosciadia both had been synthesized earlier (66AJC151). [Pg.148]

The crude drug, Adhatoda vasica, is used in India as a remedy for asthma. According to Chopra, vasicine produces broncho-dilation and might be used clinically as an expectorant. A detailed pharmacological examination of peganine in comparison with harmine has been made by Tutaev and Makarova. ... [Pg.620]

The DEPT and broad-band decoupled C-NMR spectra of vasicinone, C11H10N2O2, isolated from a plant Adhatoda vasica, are shown. Spec-... [Pg.125]

It was recently observed that a iplant, Adhatoda vasica, long used in Indian herbal medicine (the source of many therapeutic leads) for the relief of cough and respiratory tract congestion, did appear to reduce the quantity and viscosity of sputum. The plant was studied and its active alkaloid named vasicine. The tricyclic quinazoline structure (XXVIII) was then reduced to fragments and a series of derivatives prepared [350]. From these bromhexine (XXIX, Na 274, Bisolvon)... [Pg.44]

Nepal. Decoction of the rhizome, mixed with Artemisia dubia, is taken orally as an antipyretic. The juice is mixed with butter and massaged on the chest and throat to cure cough. The juice is taken orally for throat infection . Decoction of the rhizome, mixed with the Justicia adhatoda, is mixed in warm water and salt and then taken orally twice a day for 2-3 days to treat abdominal pain . [Pg.511]

Certain alkaloids such as vasicine obtained from plant Adhatoda vasica act as potent expectorant and mucolytic agent. Bromhexine, a derivative of vasicine depolymerises mucopolysaccharides directly and by liberating lysosomal enzymes. Another compound acetylcysteine opens disulfide bonds in mucoproteins present in sputum and decrease its viscosity. Carbocisteine acts in same manner. [Pg.230]

N.A. Justicia adhatoda L. Alkaloids, volatile oil." For bronchitis, tuberculosis. [Pg.274]

Ephedra distachya, Fritillaria verticillata, Justicia adhatoda, Lobelia siphilitica, Medicago sativa, Nicotiana tabacum, Pedicularis palustris, P. canadensis, Physalis alkekengi, P franchetti, P pubescene, Picrasma excelsa, Swertia chirata, Valeriana officinalis, Veratrum viride, Verbena officinalis, Viscum album... [Pg.502]

Ranunculaceae) Adhatoda Vasica (Acanthaceae) India Leaf Bromhexine Ambroxol (semisynthetic derivatives of alkaloid vasicine)... [Pg.385]

Plant extracts are also added like rosemary, adhatoda, withania, asparagus, and woodfordia have various medicinal properties... [Pg.255]

Adhatoda vasica, Justicia adhtoda (Acanthaceae) [leaf], Lunaria spp. (Cruciferae),... [Pg.245]

In 1888, Hooper first investigated the pharmacological action of an extract of Adhatoda vasica Nees containing compound 184. In 1925, Ghose and Sen isolated this component and named it vasicine. In 1934, Spath and Nikawitz isolated an alkaloid from Peganum harmala and named it pe-ganine, but soon afterward Sp th and Kuffner showed it to be identical with vasicine. This alkaloid (184) was found not only in Adhatoda... [Pg.317]

Deoxypeganine or deoxyvasicine (124) was isolated from Adhatoda va-sica, Peganum and Peganum nigellastrum ... [Pg.320]

Vasicinolone (188) and adhatodine (195) were obtained from Adhatoda vasicc, and anisotine (196) from Adhatoda vasica and Anisotes sessili-florus. ... [Pg.320]

Other compounds isolated from Peganum harmala included deoxype-ganidine (190), peganidine (189), and dipegine (192) and from Adhatoda vasica, vasicoline (199), vasicolinone (200), and vasicol (191), - ... [Pg.321]

Adhatoda vasica Vashika Acanthaceae Shrub Leaves Fever, Bronchitis... [Pg.212]

See other pages where Adhatoda is mentioned: [Pg.16]    [Pg.617]    [Pg.619]    [Pg.784]    [Pg.302]    [Pg.40]    [Pg.511]    [Pg.25]    [Pg.73]    [Pg.542]    [Pg.16]    [Pg.520]    [Pg.4]    [Pg.377]    [Pg.377]    [Pg.377]    [Pg.267]    [Pg.270]    [Pg.169]    [Pg.15]    [Pg.320]    [Pg.320]    [Pg.320]    [Pg.101]    [Pg.102]    [Pg.111]   
See also in sourсe #XX -- [ Pg.2 , Pg.5 , Pg.8 , Pg.10 , Pg.11 , Pg.14 , Pg.15 ]

See also in sourсe #XX -- [ Pg.126 ]

See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.569 , Pg.570 , Pg.660 ]



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Adhatoda vasica

Justicia adhatoda

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