Adenomatoid tumor

Some epithelial mesotheliomas are composed of small cysts formed by uniform cuboidal mesothelial cells and associated numerous blood vessels (Fig. 12.68). This type of mesothelioma may be difficult to differentiate from a vascular neoplasm. The epithelial mesothelial cells may contain intracytoplasmic hemosiderin (Fig. 12.69). The immunophenotype of such neoplasms is identical to that of other epithelial mesotheliomas. The vascular proliferation may be related to an endothelial growth factor produced by neoplastic mesothelial cells.Adenomatoid tumors are localized benign mesothelial proliferations that most frequently occur in the epididymus and cornua of the uterus.Adenomatoid tumors have been identified in the adrenal gland and pancreas. These tumors are formed by uniform small cuboidal cells and can appear invasive. They express keratin and other markers of mesothelial cells and have the characteristic ultrastruc-tural features of mesothelial cells. Adenomatoid tumors have also been reported in the pleura. Hyperplastic... 

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Isotalo PA, Keeney GL, Sebo TJ, et al. Adenomatoid tumor of the adrenal gland A clinicopathologic study of five cases and review of the literature. Am J Surg Pathol. 2003 27 969-977. 

Overstreet K, Wixum C, Shabaik A, et al. Adenomatoid tumor of the pancreas A case report with comparison of histology and aspiration cytology. Mod Pathol. 2003 16 613-617. 

Staining for cytokeratin and calretinin helps with the identification of adenomatoid tumors. 

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Youngs LA, Taylor HB. Adenomatoid tumors of the uterus and fallopian tube. Am J Clin Pathol. 1967 48 537-545. 

Salazar H, Kanbour A, Burgess F. Ultrastructure and observations on the histogenesis of mesotheliomas, adenomatoid tumors, of the female genital tract. Cancer. 1972 29 141-152. 

Mai KT, Yazdi HM, Perkins DG, et al. Adenomatoid tumor of the genital tract Evidence of mesenchymal cell origin. Pathol Res Pract. 1999 195 605-610. 

Schwartz EJ, Longacre TA. Adenomatoid tumors of the female and male genital tracts express WTl. Int J Gynecol Pathol. 2004 23 123-128. 

Podoplanin Mesothelioma, adenomatoid tumor, lymphangioma Vascular tumors, skin adnexal carcinomas Mesothelial cells, endothelial cells of lymphatic vessels, granulosa cells, osteocytes, ependymal cells... 

Ozolek JA, Hunt JL. Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH) comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa. Am J Surg Pathol. 2006 30(12) 1576-1580. 

Mesotheliomas are separated into epithelial sarcomatous and mixed types. In one-third of all tumors, both epithelial and sarcomatous elements can be found. Epithelial tumors are separated into tubulo-papiUary, epithelioid, adenomatoid, and desmoplastic varieties. The sarcomatous variants are either fibro-sarcomatous or desmoplatic (Miller et al. 1996). 

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