Adair model

KOSHLAND-NEMETHY-FILMER MODEL Adair model,... 

The binding parameters Ki,Kz, Ki, and Aj represent statistical weights for the states of one, two, three, and four oxygen molecules bound.. An extensive literature has developed since 1925 to improve upon the Adair model to reduce the number of parameters to fewer than four, to interpret the parameters... 

Adair (1925) introduced the stepwise binding model which, for Hb, produces the so-called Adair equation (see Section 2.3). This has the form... 

Note that the Adair equation does not provide a reason for why identical sites would have different dissociation (or association) constants. See Allosterism Cooperativ-ity, Koshland-Nemethy-Filmer Model... 

Linked-function mechanisms for cooperative binding interaction of metabolites and/or drugs, based on the presence of two or more different conformational states of the protein or receptor. See Adair Equation Cooperative Ligand Binding Hemoglobin Hill Equation Plot Koshland-Nemethy-Filmer Model Monod-Wyman-Changeux Model Negative Cooperativity Positive Cooperativity... 

The chief limitation of this plotting method is that, unlike the Adair Equation, the plot requires that the system obey all of the conditions required by the MWC model. This assumption will often prove to be incorrect ... 

A model used to explain cooperativity on the basis of ligand-induced changes in conformation that may or may not alter the subunit-subunit interfaces of oligomeric enzymes and receptors. This model has also been referred to as the Adair-Koshland-Nemethy-Filmer model (AKNF model), the induced-fit model, and the sequential model. 

ADAIR EQUATION COOPERATIVE LIGAND BINDING HILL EQUATION PLOT KOSHLAND-NEMETHY-EILMER MODEL MONOD-WYMAN-CHANCEUX MODEL NEGATIVE COOPERATIVITY POSITIVE COOPERATIVITY HEMOGLOBIN ALLOTOPIC EFFECT Allowed electronic transitions,... 

COOPERATIVITY ALLOSTERISM INDUCED FIT MODEL MONOD-WYMAN-CHANGEUX MODEL INDEPENDENT BINDING LINKED FUNCTIONS ADAIR EQUATION POSITIVE COOPERATIVITY NEGATIVE COOPERATIVITY KOSMOTROPES CHAOTROPIC AGENTS HOFMEISTER SERIES Kp, Kq, K .. . ... 

Using these assumptions, it is possible to describe the binding of oxygen by four successive binding constants. This is formally equivalent to the Adair equation the KNF model may be considered as a molecular interpretation of that equation. In general, the number of constants required is equal to the number of binding sites, unlike the situation in the MWC model, which always uses three. 

The O2 binding properties of hemoglobin have been mainly represented by two methods as shown in Figure 9. First, the model proposed by Adair and Koshland uses four successive... 

Mathematically, cooperativity observed in ligand binding has been described by both the Hill and Adair equations. The derivations of these equations are modeled on the classic textbook example of first ligand binding, and then specifically the Hill and Adair equations (2,3). First, consider the simple binding of L... 

With the mathematical evaluation of cooperativity based on the Hill and Adair equations, the question remains. How does the enzyme convey ligand binding between sites Historically, the mechanisms by which proteins convey cooperativity in ligand binding have been described by two models Monod-Wyman-Changeaux (6) (MWC) and Koshland-Nem-ethy-Filmer (7)/Dalziel-Engel (8) (KNF/DE). These two models serve as starting points to... 

Imai. K. Analyses of oxygen equilibria of native and chemically modified human adult hemoglobins on the basis of Adair s stepwise oxygenation theory and the allosteric model of Monod. Wyman, and Changeux. Biochemistry 1973, 12. 798-807. 

The concerted symmetry model is much more versatile than simple sequential models described by Adair or Hill. This model is endowed by the variable values of Kr, L, and c, and therefore may provide explanations for many properties of allosteric enzymes and proteins, including... 

The influence of experimental conditions on Hill parameter estimation is described by Glende and Reich (1972). According to Reich et al. (1972), a nonlinear regression with a minimum of 15 measuring points should be used for an unbiased determination of parameters. Also, the Hill model has been extended by Adair (1925) to allow for the existence of stable, partly liganded intermediates. 

Acylmercaptan see Thioester. Adair-Koshland-Nemethy-Filmer model see... 

Linda Adair, Ph.D., is a professor of nutrition at the School of Public Health, University of North Carolina at Chapel Hill, and fellow of the Carolina Population Center. Her research interests include the determinants of early childhood feeding and growth patterns and obesity in childhood and adolescence. She has designed and implemented population-based health, demographic, and nutrition surveys with a special emphasis on longitudinal modeling. She received her Ph.D. from the University of Pennsylvania. Dr. Adair is a member of the Society for International Nutrition Research and the American Society for Nutritional Sciences. 

One of the earliest models of hemoglobin cooperativity w as the Adair equation, developed by G Adair in 1925 [6, which can be expressed as... 

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