Acylalanine fungicides

RNA Synthesis. The phenylamides comprise a diverse group of systemic compounds of which the acylalanines are the most successful (Figure 4.11). The acylalanine fungicides are systemic, mainly via the... 

Staub, T., Dahmen, H., Urech, P., and Schwinn, F. 1979. Failure to select for in vivo resistance in Phytophthora infestans to acylalanine fungicides. Plant Dis. Rep. 63, 385-389. 

Within the past ten years, the market introduction of several new types of fungicides has significantly improved the prospects of controlling the Oomycetes. They belong to five different chemical classes the carbamates, the isoxazoles, the cyanoacetamide oximes, the etheyl phosphonates, and the acylalanines and related compounds. The chemical structures of those chemicals that have reached the commercial level are shown in Figures 3-5 (29, revised). Trade names, formulations and first reports are summarized in Table II (29, revised). The biological characteristics of these new fungicides and their impact on disease control have been reviewed by several authors (10, 16, 27, 28, 29, 33). 

The new compounds are used at substantially lower rates than the conventional protectant fungicides (Table V), thus reducing the amount of chemicals brought into the environment. In addition, the acylalanines can be used as seed dressings at extremely low rates. 

Bruin, G.C.A. 1980. Resistance in Peronosporales to acylalanine-type fungicides. Ph.D. thesis Univ. Guelph, Ontario, Canada, 110... 

Staub, T., Dahmen, H. and Schwinn, F.J. 1978. Biological characterization of uptake and translocation of fungicidal acylalanines in grape and tomato plants. Z. Pflanzenkr. Pflan-zenschutz 85, 162-168. 

The new fungicides being developed for use on grapes in the US fall into three categories ergosterol biosynthesis inhibitors acylalanines, and dicarboximides. 

Acylalanines are a new class of fungicides, two members of which metalaxyl (CGA 48 988), methyl N-(2,6-dimethylphenyl)-N-(2-methoxyacetyl)-DL-alaninate,... 

S.4.5.6 Acylalanines. These are another important new class of fungicides introduced by Ciba-Geigy during the last five years, but already resistance to them has been encountered in some countries and thus they have had to be used in mixtures with other fungicides. 

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