Acyclovir cream

Load items 5, 6, and 7 in fat-melting vessel and melt at 70°C. Maintain temperature at 70° 2°C. 

Heat item 8 in mixer at 90°C. Cool down to 70°C. Add item 2 in item 8 at 70°C and stir to dissolve. Add item 4 to mixer (step 2.2) and mix. Maintain temperature at 70° 2°C. 

Handbook of Pharmaceutical Manufacturing Formulations Semisolid Products 

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Essentially just an FT-IR instrument coupled to a GC, thus allowing IR spectra of compounds eluting from the GC column to be obtained. More useful for structure elucidation rather than quantitative studies. The detector is sensitive to the 10 ng level. Used as a tool for qualitative identification. There are some examples of quantitative applications, e.g. determination of propandiol in acyclovir cream. ... 

Sixteen adult patients with a history of recurrent attacks of herpetic lesions, eight labial and eight genital, were treated by topical application of honey for one attack and acyclovir cream for another attack. 

Karlsmark, T. Goodman, J. Drouault, Y. Lufrano, L. Pledger, G. the C.S.S. Group. Randomized clinical study comparing Compeed cold sore patch to acyclovir cream 5% in the treatment of herpes simplex labialis. J. Eur. Acad. Dermatol. Venereol. 2008, 22 (10), 1184-1192. 

Cream - Systemic absorption of acyclovir from the cream is minimal in adults. 

Topical acyclovir (Zovirax) is available as a 5% ointment topical penciclovir (Denavir), as a 1% cream for the treatment of recurrent orolabial herpes simplex virus infection in immunocompetent adults. Adverse local reactions to acyclovir and penciclovir may include pruritus and mild pain with transient stinging or burning. 

FIGURE 13.10 Parameters assessed in a two-armed, randomized, double-blind clinical study in RHL patients with two formulations containing 5% acyclovir ethosomal acyclovir (EA) vs. Zovirax cream (ZC). (a) Data obtained in parallel arm (b) data obtained in crossover arm (c) number of abortive lesions (%). (Reproduced from Touitou, E. et al., Drug Dev. Res., 50, 406, 2000. With permission from John Wiley Sons.)... 

Acyclovir can be applied topically as a cream to treat cutaneous and mucosal infections. This drug can also be administered systemically, either orally or intravenously in severe, acute infections. 

In acyclovir-resistant mucocutaneous HSV infections, lower doses of foscamet (40 mgAg every 8 hours for 7 days or longer) are associated with cessation of viral shedding and complete healing of lesions in -75% of patients. Foscamet also appears to be effective in acyclovir-resist-ant VZV infections. Topical foscamet cream may be useful in chronic acyclovir-resistant infections in immunocompromised patients. 

Strand A, Bottiger D, Gever LN, Wheeler W. Safety and tolerability of combination acyclovir 5% and hydrocortisone 1% cream n adolescents with recurrent herpes simplex labiahs. Pediatr Dermatol 2012 29(1) 105-10. 

A clinical investigation was undertaken by Passos et al. aiming to evaluate the efficiency of a cream from U. tomentosa for the treatment of the herpes labials. The assessment of clinical efficiency of U. tomentosa was evaluated against acyclovir, a control drug. The study has shown that the cream of U. tomentosa is significantly more potent than acyclovir with no adverse reactions [66]. 

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