Acute lung injury models

V6. Villar, J., Edelson, J. D., Post, M., Mullen, J. B. M., and Slutsky, A. S., Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. Am. Rev. Respir. Dis. 147, 177-181 (1993). 

J.P. Meinhardt, U. Friess, H.J. Bender, R.B. Hirschl, M. Quintel, Relationship among cardiac index, inspiration/expiration ratio, and perfluorocarbon dose during partial liquid ventilation in an oleic acid model of acute lung injury in sheep, J. Pediatr. Surg. 40 (2005) 1395-1403. 

Studies have indicated that leukocytes play a critical role in the activation of coagulation in patients with septicemia and in animal models of acute lung injury (69). One study has presented direct evidence indicating the role of tissue factor expression on activated endothelial cells on in vivo thrombogenesis (70). 

Gonzalez PK et al (1996) Role of oxidant stress in the adult respiratory distress syndrome Evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury. Shock 6 S23-S26... 

In an animal model, acute lung injury was inhibited by pretreatment with clarithromycin or roxithromycin, which significantly ameliorated bleomycin-induced increases in the total cell and neutrophil counts in bronchoalveolar lavage fluids and wet lung weight (25). Pretreatment with clarithromycin or roxithromycin also suppressed inflammatory cell infiltration and interstitial lung edema. Pretreatment with azithromycin was much less effective. 

Nonas, S., Miller, I., Kawkitinarong, K., Chatchavalvanich, S., Gorshkova, I., Bochkov, V.N., Leitinger, N., Natarajan, V., Garcia, J.G., and Birukov, K.G. (2006). Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med 173, 1130-8. 

Nonas, S. et al. Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am. J Respir. Crit Care Med. 173 (2006) 1130-8. 

Table 4.1 Evidence for arachidonic acid metabolite synthesis or release in models of acute lung injury...

Meaningful interpretation of eicosanoid levels in plasma or pulmonary oedema fluid during clinical sepsis or ARDS is complicated by the large number of uncontrolled variables compared with experimental sepsis or models of acute lung injury. These include diverse etiological factors precipitating sepsis and ARDS, variation in the stage of severity of these inflammatory conditions... 

ANIMAL MODELS OF DISEASE FOR FUTURE TOXICITY PREDICTIONS TABLE 18.6 Models of Acute Lung Injury"... 

Other animal models have been employed to more closely mimic IPF that can follow an acute lung injury. In this syndrome, the pulmonary fibrosis occurs as a result of a severe lung injury (acute lung injury/ARDS), resulting in severe complications, with secondary pulmonary hypertension and... 

Matute-Bello, G., Frevert, C.W., and Martin, T.R. (2008) Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 295, L379-L399. 

Eickmeier O., Seki H., Haworth O., Hilherath J. N., Gao F., Uddin M., Croze R. H., Carlo T., Pfeffer M. A., Levy B. D. 2013. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury, Imnmnolo. 6(2) 256-266. 

---