Actively caring described

The above examples can be extended to the majority of older and newer active substances described in, e.g., The Pesticide Manual and to numerous relevant metabolites featuring hydroxyl or carboxyl moieties or even for conjugates however, there remain various active substances and metabolites that still require careful and extensive method development. 

After medicinal chemists nominate a compound as a developmental target, process chemists initiate process research and development activities. As described elsewhere in the book, process research chemists carefully analyze the medicinal chemistry route and make suitable modifications. Chemical process development converts a bench synthetic procedure into a safe, robust, and economically viable process suitable for manufacturing. The concept of process robustness is described as follows ... 

The emphasis changes in Electroactive Polymer Electrochemistry, Part 2 Methods and Applications, where methodology and applications is addressed. The volume begins (Chapter 5) with a contribution by Morton-Blake and Corish. These contributors have been very active in the area of atomistic simulation of matter transport phenomena in solid materials. In the present contribution they describe in a lucid manner the results of their recent work in applying the methodology of atomistic simulation to quantify dopant transport processes in electroactive polymers. The idea of simulation is continued in Chapter 6, where Cassidy carefully describes the application of digital simulation protocols to charge transport in... 

R a e describe specifically the observed ACTIVELY CARING behavior (see back for e>ramples)... 

If stimulus overload can affect people s attention to an emergency, it can certainly reduce attention to common everyday situations that are not very obtrusive, but nevertheless require actively caring behavior. Consider, for example, the various needs for proactive behavior that can prevent an injury. Environmental hazards are easy to overlook, especially in a busy and noisy workplace requiring focused attention on a demanding task. Even less noticeable and attention-getting are the ongoing safe and at-risk behaviors of people around us. Yet, these behaviors need proactive support or correction as in the safety coaching approach described in Chapter 12. 

The influence of context in determining whether we actually care for another person s safety cannot be overemphasized. Context actually can influence each step of the Latane and Darley (1970) decision model described previously and summarized in Figure 14.13. The context in which behavior occurs can affect one s evaluation of the costs and benefits of helping vs. not helping a victim. In other words, the perceived consequences of actively caring depend to a significant extent on the environmental and social context in which the relevant behaviors occur. Let us look more closely at this context variable, and consider its impact on safety-related behavior. 

The impact of an intervention can be measured by comparing perception surveys given before and after implementation. At one plant, our baseline Safety Culture Survey indicated that secretaries had below-average levels of perceived empowerment, as assessed by the measures of self-efficacy, personal control, and learned optimism described earlier in Chapter 15. A special recognition intervention was devised and later the survey was administered again to measure changes in the five actively caring person states as well as safety perceptions and attitudes. 

Manufacture. Trichloromethanesulfenyl chloride is made commercially by chlorination of carbon disulfide with the careful exclusion of iron or other metals, which cataly2e the chlorinolysis of the C—S bond to produce carbon tetrachloride. Various catalysts, notably iodine and activated carbon, are effective. The product is purified by fractional distillation to a minimum purity of 95%. Continuous processes have been described wherein carbon disulfide chlorination takes place on a granular charcoal column (59,60). A series of patents describes means for yield improvement by chlorination in the presence of dihinctional carbonyl compounds, phosphonates, phosphonites, phosphites, phosphates, or lead acetate (61). 

A careful use of solvent effects should be of great assistance in synthetic chemistry. For example, it may be predicted from the solvent effects described above that in the reaction of 2,4-dichloroquinohne with piperidine the a y ratio should increase in the less polar solvents, although the result might be obscured by the mutual influence of the two chlorine substituents. Nitro-activated benzenes support this prediction since ortho para ratios of 4.2 in methanol and 69 in benzene were observed in the reaction of 2,4-dichloronitrobenzene with piperidine. ... 

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