Active pharmaceutical counterions analysis

Another major ion chromatography application is the analysis of active ingredient counterions. Frequently, drug substances are formulated as salts in order to achieve specific pharmaceutical properties (such as improved solubility or control of dissolution rate). The analysis of... 

This chapter reviews the imderlying principles of ion chromatography and its applications in pharmaceutical analysis. An overview of eluent systems, applications of gradients, electrolytic eluent generation, suppressors and stationary phases is provided. Application of ion chromatography to the confirmation of counterions, active ingredient analysis, competitive analysis and development work are discussed. 

The separation and detection of small organic and inorganic ions is an important activity in the pharmaceutical industry. CE is routinely used for ion analysis in the pharmaceutical industry for a number of applications, these include counterion determination, stoichiometry, salts, and excipients in drug formulations. Most pharmaceutical molecules are charged and are commonly manufactured... 

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