Acromegaly Glucose tolerance

Routinely assess acromegaly complications, including blood pressure, glucose tolerance, fasting lipid profile, cardiac evaluations (if clinically indicated), colonoscopy, dual-energy x-ray absorptiometry (DEXA) scan (hypogonadal only), evaluation of residual pituitary function, and evaluation of sleep apnea. 

Ronchi C, Epaminonda P, Cappiello V, Beck-Peccoz P, Arosio M. Effects of two different somatostatin analogues on glucose tolerance in acromegaly. J Endocrinol Invest 2002 25(6) 502-7. 

Ho KK, Jenkins AB, Furier SM, et al. Impact of octreotide, along-acting somatostatin analogue, on glucose tolerance and insuUn sensitivity in acromegaly. Clin Endocrinol 1992 36 271-279. 

Sato K, Takamatsu K, Hashimoto K. Short-term effects of octreotide on glucose tolerance in patients with acromegaly. Endocr J 1995 42 739-745. 

Koop BE, Harris AG, Ezzat S. Effect of octreotide on glucose tolerance in acromegaly. Eur J Endocrinol 1994 130 581-586. 

The oral glucose tolerance test (see p.. 58) is commonly used in the diagnosis of diabetes mcliitus but is also u.sed to investigate growth honnone response in acromegaly. 

Lack of suppression of serum GH levels in response to a glucose tolerance test is the diagnostic test for acromegaly. 

As a result of the metabolic effects of GH, the clinical course of acromegaly may be complicated by impaired glucose tolerance or even overt diabetes mellitus, as occurred with Sam Atotrope. 

Calao A, Auriemma RS, Savastano S, Galdiero M, Grasso LFS, Lombardi G, Pivonello R. Glucose tolerance and somatostatin analog treatment in acromegaly a 12-month study. J Clin Endocrinol Metab 2009 94 2907-14. 

The condition which results from excess growth hormone secretion in adults, the usual cause being a pituitary adenoma. The condition is characterized by increases in bulk of the bones and soft tissues, especially of the jaw, hands and feet. Because growth hormone is involved in glucose homeostasis, impaired glucose tolerance can occur. Acromegaly can be diagnosed biochemically by ... 

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