Acquired Long QT Syndrome

Karagueuzian, H.S. (2000) Acquired long QT syndromes and the risk of proarrhythmia. Journal of Cardiovascular Electrophysiology, 11, 1298. [Pg.81]

Sanguinetti, M.C. and Mitcheson, J.S. (2005) Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends in Pharmacological Sciences, 26, 119-124. [Pg.104]

Gintant, G.A., Limberis, J.T., McDermott, J.S., Wegner, C.D. and Cox, B.F. (2001) The canine purkinje fiber an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. Journal of Cardiovascular Pharmacology, 37, 607-618. [Pg.455]

Propranolol, nadolol, timolol, penbutolol, carteolol, sotalol, and pindolol Bronchial asthma or bronchospasm, including severe chronic obstructive pulmonary disease. Metoprolol Treatment of Ml in patients with a heart rate less than 45 beats/min significant heart block greater than first degree (PR interval 0.24 seconds or more) systolic blood pressure less than 100 mm Hg moderate to severe cardiac failure. Sotalol Congenital or acquired long QT syndromes. [Pg.524]

Khan IA Clinical and therapeutic aspects of congenital and acquired long QT syndrome. Am J Med 2002 112 58. [PMID 11812408]... [Pg.298]

Chiang CE. Congenital and acquired long QT syndrome. Current concepts and management. Cardiol Rev. 2004 12 222-234. [Pg.329]

Roden DM, Viswanathan PC. Genetics of acquired long QT syndrome. J Clin Invest. 2005 115 2025-2032. [Pg.329]

Witchel HJ, Hancox JC. Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 2000 27(10) 753-66. [Pg.273]

Viswanathan PC, Rudy Y. 2000. Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. Circulation 101 1192-98... [Pg.458]

Bauman JL. The role of pharmacokinetics, drug interactions and pharmacogenetics in the acquired long QT syndrome. Eur Heart J 2001 3 K93-100. [Pg.355]

The impairment of critical cellular functions can result in systemic toxicities such as those associated with the neuromuscular system (tremor, cardiac arrhythmia, and paralysis). renal (microtubule function), and vasculature (leaky blood vessels). A noteworthy example is the acquired long QT syndrome (LQTS) associated with blockade of cardiac ion channels (14-16). LQTS results in cardiac arrhythmias, torsade de pointes, ventricular fibrillation, and can lead to sudden death. One such ion channel is the HERG protein, respon-... [Pg.76]

KvLQTl (KCNQl), HERG (KCNH2), SCN5A Acquired long-QT syndrome (patients with drug-associated torsades de pointes) Mutations in these genes 5/92 patients has mutations 55... [Pg.74]

Sotalol is contraindicated in patients with bronchial asthma, sinus bradycardia, second- and third-degree AV block (unless a functioning pacemaker is present), congenital or acquired long QT syndromes, cardiogenic shock, or uncontrolled congestive heart failure. [Pg.650]

Witchel HJ, Hancox JC (2000) Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 27 753-766 Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC (2002) Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett 512 59-66... [Pg.108]

Itoh H, Crotti L, Aiba T et al (2016) The genetics underlying acquired long QT syndrome impact for genetic screening. Eur Heart J 37 1456-1464... [Pg.68]

Rentrop KP, Feit F (2015) Reperfusion therapy for acute myocardial infarction concepts and controversies from inception to acceptance. Am Heart J 170 971-980 Romero L, Trenor B, Yang PC, Saiz J, Clancy CE (2015) In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol 87 271-282... [Pg.70]

Camm AJ, Malik M, Yap YG (2004) Acquired long QT syndrome. Euture/BlackweU Publishing, Malden... [Pg.157]

Totterman KJ, Tuito H, PelUnen T (1982) Overdrive pacing as treatment of sotalol-induced ventricular tachyarrhythmias (torsade de pointes). Acta Med Scand Suppl 668 28-33 Tsutsui K, Hayami N, Kunishima T et al (2012) Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. Circ J 76 2343-2347 Turner JR (2010) New drug development an introduction to clinical trials, 2nd edn. Springer, New York... [Pg.298]

Barra S, Agarwal S, Begley D, ProvidSncia R (2014) Post-acute management of the acquired long QT syndrome. Postgrad Med J 90 348-358... [Pg.298]

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