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Adenine acidity

Cellular Protein Biosynthesis. The process of cellular protein biosynthesis is virtually the same in all organisms. The information which defines the amino acid sequence of a protein is encoded by its corresponding sequence of DNA (the gene). The DNA is composed of two strands of polynucleotides, each comprising some arrangement (sequence) of the four nucleotide building blocks of the nucleic acids adenine (A), thymine (T),... [Pg.196]

The result of this biosynthesis is that the product is nicotinic acid mononucleotide rather than free nicotinic acid. Ingested nicotinic acid is converted to nicotinic acid mononucleotide which, in turn, is converted to nicotinic acid adenine dinucleotide. Nicotinic acid adenine dinucleotide is then converted to nicotinamide adenine dinucleotide. If excess nicotinic acid is ingested, it is metabolized into a series of detoxification products (Fig. 4). Physiological metabohtes include /V-methylnicotinamide (19) and A/-methyl-6-pyridone-2-carboxamide (24) (1). [Pg.50]

The sugars are typically ribose (ribonucleic acids, RNA), or 2-deoxyribose (deoxyribonucleic acids, DNA). There are five common bases in nucleic acids adenine (A) thymine (T) uracil (U) cytosine (C) and guanine (G). DNA polymers incorporate the four bases. A, T, C, and G, and RNA, the set A, U, C, and G. [Pg.94]

Another property of pyrimidines and purines is their strong absorbance of ultraviolet (UV) light, which is also a consequence of the aromaticity of their heterocyclic ring structures. Figure 11.8 shows characteristic absorption spectra of several of the common bases of nucleic acids—adenine, uracil, cytosine, and guanine—in their nucleotide forms AMP, UMP, CMP, and GMP (see Section 11.4). This property is particularly useful in quantitative and qualitative analysis of nucleotides and nucleic acids. [Pg.330]

NADP can be converted to nicotinic acid adenine dinucleotide phosphate (NAADP), which has distinct functions in the regulation of intracellular calcium stores. The studies of these new roles of NAD(P) in metabolism are in their early stages, but they might soon help to better understand and explain the symptoms of niacin deficiency ( pellagra) [1]. [Pg.851]

The complexity of the HCN oligomerisation reaction was also studied by Schwartz et al. (1984) in Nijmegen. The reactions worked best at a pH value which lies near the pK value of HCN. A list of the products of oligomerisation includes 38 compounds, including orotic acid, adenine, guanine and glycine, as well as more complex molecules such as isoleucine, glutamic acid, diaminosuccinic acid and... [Pg.104]

Purines One of the two types of bases in the nucleic acids adenine and guanine. [Pg.314]

Brailoiu, E., Patel, S. and Dun, N. J. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca2+ stores critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). Biochem. J. 373 313-318, 2003. [Pg.390]

LEMS Lambert-Eaton myasthenic syndrome NAADP nicotinic acid-adenine dinucleotide phosphate... [Pg.965]

Yusufi ANK, Cheng J, Thompson MA, Chini EN, Grande JP 2001 Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells. Biochem J 353 531—536... [Pg.41]

In smooth muscle, just as in other cells, extracellular stimuli typically evoke an increase in cytosolic Ca2+ concentration ([Ca2+]c) by stimulating release of Ca2+ from intracellular stores or Ca2+ entry across the plasma membrane. Members of two closely related families of intracellular Ca2+ channels, ryanodine receptors and the receptors for inositol-1,4,5-trisphosphate (InsP3) appear to be expressed in all smooth muscle cells and they provide the most important route for release of Ca2+ from the sarcoplasmic reticulum (Sutko Airey 1996). The roles of additional Ca2+-mobilizing messengers, such as nicotinic acid adenine dinucleotide... [Pg.91]

There are five common bases found in nucleic acids. Adenine (A), guanine (G) and cytosine (C) are found in both DNA and RNA. Uracil (U) is found only in RNA and thymine (T) only in DNA. The structures of these bases are shown in Figure 13.2. Adenine and guanine are purine bases while uracil, thymine and cytosine are the pyrimidine bases. [Pg.444]

Treatment of 9-(/ -D-ribofuranosyluronic acid)adenine with diphenylphosphoro-chloridate and orthophosphate or tripolyphosphate yields (62) and (63), which, although unstable, inhibit rabbit AMP aminohydrolase and pyruvate kinase, respectively, with behaviour characteristic of active-site-specific reagents.98 Adenylate kinases from several sources are inactivated by iV6-[2- and 4-fluorobenzoyl]-adenosine-5 -triphosphates, with kinetics characteristic of active-site labelling, although these compounds were without effect on yeast hexokinase and rabbit pyruvate kinase.99... [Pg.166]

The presence of the cation protonated on N-1 cannot account for the fluorescence of aqueous acidic adenine solutions (pH = 2), since the 1-methyl derivative does not fluoresce under the same conditions (Borresen, 1967). It has therefore been suggested that other tautomeric forms of the cation are also present, the fluorescent tautomer probably being protonated on the amino-group with another proton on N-7. Quantum mechanical calculations (Veillard and Pullman, 1963) indicate similar proton affinity for N-1 and N-3, and a lesser one for N-7. There are numerous calculations in the literature on the electronic structure of adenine (see Boyd, 1972, and references quoted therein) and a recent one on N-7-H and N-9-H tautomers protonated on N-1 (Jordan and Sostman, 1972). The N-9-H form is preferred according to hoth MINDO and CNDO/2 calculations. [Pg.324]

The significance of these in vitro enzyme inhibition studies is uncertain, in view of the evidence that has been presented concerning the sensitivity of cancer cells to feedback inhibition by these nucleotides. On the other hand, 6-chloropurine inhibits the de novo biosynthesis of nucleic acid guanine but not of nucleic acid adenine in sarcoma 180 ascites cells [319],... [Pg.98]

Alkaloids that contain a purine skeleton (see Section 4.7) are commonly known as purine alklaoids, e.g. caffeine and theobromine. We have already learnt that two of the bases in nucleic acids, adenine and guanine, are purines. [Pg.300]

Nicotinic acid adenine dinucleotide phosphate (NAA 315 Nicotinic acid hydroxylase 825 Nidogen 437 Ninhydrin 120,121s Nitrate reductase(s)... [Pg.925]

NAADP = Nicotinic Acid Adenine Dinucleotide Phosphate... [Pg.548]

Nucleotides play important roles in all major aspects of metabolism. ATP, an adenine nucleotide, is the major substance used by all organisms for the transfer of chemical energy from energy-yielding reactions to energy-requiring reactions such as biosynthesis. Other nucleotides are activated intermediates in the synthesis of carbohydrates, lipids, proteins, and nucleic acids. Adenine nucleotides are components of many major coenzymes, such as NAD+, NADP+, FAD, and CoA. (See chapter 10 for structures of these coenzymes.)... [Pg.535]

On the basis of several analytical studies (differential thermal analysis, fluorescence, CPMAS solid-state NMR spectroscopy and others) [56-58] two models have been proposed to describe the structure of HCN-polymers, the Umemoto [59] and the Volker models [60]. In the Volker model, HCN polymerizes to extensive double-ladder rod-like structures, while a simpler mono-ladder pattern was hypothesized by Umemoto (Fig. 1). Irrespective of the structure assumed by HCN-polymers, a large panel of purine, imidazole and pyrimidine derivatives can be obtained by hydrolysis of these materials. In 1963, Lowe described the first example of acidic hydrolysis of the HCN-polymer (boiling 6.0 N HC1) to yield amino acids, carboxylic acids, adenine and hypoxanthine (Scheme 4). [Pg.34]

NAD(P)H nicotinic acid adenine dinucleotide (phosphate), reduced form NMR nuclear magnetic resonance (spectroscopy)... [Pg.186]

The most generally interesting intracellular metabolites are the adenine nucleotide phosphates (ATP/ADP/AMP) and the nicotinic acid/adenine dinucleotide phosphates (NAD(P)H/NAD(P)). The pool concentrations and ratios of these can serve as markers for the physiological status of a culture. [Pg.192]

There are only two purine bases found in nucleic acids, adenine (A), which we have already met, and guanine (G)... [Pg.1347]


See other pages where Adenine acidity is mentioned: [Pg.662]    [Pg.63]    [Pg.255]    [Pg.383]    [Pg.35]    [Pg.190]    [Pg.291]    [Pg.449]    [Pg.503]    [Pg.315]    [Pg.778]    [Pg.779]    [Pg.925]    [Pg.517]    [Pg.162]    [Pg.162]    [Pg.90]    [Pg.43]    [Pg.186]    [Pg.651]   
See also in sourсe #XX -- [ Pg.450 ]




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Adenine acids

Adenine incorporation into nucleic acids

Adenine incorporation into tissue nucleic acids

Adenine synthesis from uric acid

Adenine, pairing with thymine deoxyribonucleic acid

Flavin adenine dinucleotide fatty acid oxidation

Nicotinamide adenine dinucleotide fatty acid biosynthesis

Nicotinamide adenine dinucleotide phosphate fatty acid metabolism

Nicotinamide adenine dinucleotide reduction of pyruvic acid

Nicotinic acid adenine dinucleotide

Nicotinic acid adenine dinucleotide (NAAD

Nicotinic acid adenine dinucleotide NAADP

Nicotinic acid adenine dinucleotide mononucleotide

Nicotinic acid adenine dinucleotide phosphat

Nicotinic acid adenine dinucleotide phosphate

Nicotinic acid adenine dinucleotide phosphate NAADP)

Nicotinic acid adenine dinucleotide phosphoribosyltransferase

Nucleic acids, adenine, formaldehyde

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