Acetylcholinesterase gene structure

Taylor P, Li Y, Camp S, et al. 1993. Structure and regulation of expression of the acetylcholinesterase gene. Chem Biol Interactions 87 199-207. 

Arpagaus, M., Fedon, Y., Cousin, X., Chatonnet, A., Berge, J.-B., Fournier, D. and Toutant, J.-P. (1994) cDNA sequence, gene structure, and in wire expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans. Journal of Biological Chemistry 269, 9957-9965. 

Li, Y., Camp, S., Rachinsky, T.L., Getman, D., Taylor, P. (1991). Gene structure of mammalian acetylcholinesterase. Alternative... 

Hall, L.M., Spierer, P. (1986). The Ace locus of Drosophila melanogaster. structural gene for acetylcholinesterase with an unusual 5 leader. EMBO J. 5 2949-54. 

ANTICHOLINESTERASES are agents that inhibit cholinesterases, enzymes that fall into two main families -acetylcholinesterases (AChE) and butyrylcholinesterases (BChE). These enzymes are of related molecular structures but have different distributions, genes and substrate preferences. The enzymes have globular catalytic subunits that are the soluble form of the esterases (as in plasma or CSF), or they can be attached via long collagen tails to the cell membrane. 

Acetylcholinesterase AChE (EC 3.1.1.7) from vertebrates is deduced from a single gene (Massoulie, 2002) expressing identical enz3nne primary structures on the surface of RBCs, in S5mapses and different organs. 

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