Aceto-nitrile

Benzyl cyanide, C Hj. CH.,CN, or phenyl-aceto-nitrile, is a constituent of cress oil, and probably of neroli oil. It is a strong smelling liquid boiling at 231 5°, and having a specific gravity 1 0146 at 18°. On boiling with alcoholic potash it yields phenyl-acetic acid, which can be identified by its melting-point, 77°, and by the analysis of its silver salt. 

Wahrend l-ChIor-6-oxo-3,3-dimethyI-cyclohexen bei -2,05 Vin wasserfreiem Aceto-nitril zum 6-Oxo-3,3-dimethyl-cyclohexen (66% d.Th.) reduziert wird, erhalt man in was-serhaltigem Acetonitril, ebenfalls bei -2,05 V, 2,12-Dichlor-l-hydroxy-3-oxo-6,6,9,9-tetramethyl-tricyclo[6.3.1.02 7]dodecan (18% d. Th.)2 ... 

V-( 1,3-Pen tadienyl)pyrrolidine-l-carboxamide, 59, 8 (PENTAFLUOROPHENYL)ACETO-NITRILE, 57, 80... 

Temperature (°C) Methanol Aceto- nitrile Ethyl acetate Propan- 2-ol THF MIBK... 

This contribution reviews recent results on [Si(Pc)0]n (Pc = phthalocyaninato) solid state electrochemistry and the structural interconversions that accompany electrochemical doping/undoping processes. In aceto-nitrile/(a-Bu)4N+BF4, it is found that a significant overpotential accompanies initial oxidation of as-polymerized [Si(Pc)0]n. This can be associated with an ortho rhomb ic- te tr agonal structural transformation. 

Figure 3.59 Cyclic voltammogram of a glassy carbon electrode immersed in N2-saturated aceto-nitrile/0.2M tetraethylammonium tetrafluoroborate containing 5 x 10 3 M Re(dmbpy)(CO)3Ci, The scan rate is 100mVs 1. From Christensen et at. (1992).

A further specific assay is the HPLC-determination of bromocriptine mesilate following extraction with methanol from the dosage form using RP-18 as the stationary and aceto-nitrile/0.01 M ammonium carbonate solution 65 35 as the mobile phase. Uv-detection wavelength is set at 300 nm (26). 

Dobutamine hydrochloride may be determined in plasma levels, after extraction, on a C18 reversed-phase column eluted with 22% aceto-nitrile-78% 0.1 M phosphate buffer (pH 2.0) at 2 ml/minute. The drug and its metabolite are detected by a fluorescent detector with an excitation wavelength of 195 nm and a 330 nm emission cut off filter. The retention times of dobutamine and the 3-methoxy metabolite are 5.2 and 7.9 min., respectively. The lower limit of sensitivity is 10 ng/ml. Reproducibility is 5% over a 25-300 ng/ml range. Nylidrin is used as an internal standard (6). 

Figure 1. The current (a) and the second harmonic signal (b) obtained during the potential cycling (10 mV s"1 scan rate) from a polycrystalline silver electrode in a 0.1M LiClC>4 aceto nitrile solution.

Medi- anol Aceto- nitrile Eth- anol Ace- tone Di- oxane Isopro- panol Tetrahy- drofriran ... 

Als Losungsmitlel kann auch Methanol oder eine Benzol/Methanol-Mischung eingesetzt werden. Aceto-nitril, Tetrahydrofuran und 1,2-Dimethoxy-ethan sind dagegen ungeeignet. 

NiCIjRuCiiHik, Ruthenium(II), bis(aceto-nitrile)dichloro(-riJ-1,5-cyclo-octadiene)-, 26 69... 

To determine the effect of mobile-phase composition on the sorption behavior of TGs on reverse-phase columns, two mixtures were employed acetonitrile/ethanol (80 20) and aceto-nitrile/methanol (80 20). A very rapid analysis resulted, with excellent peak shape and adequate resolution, when ethanol was used as the secondary solvent. Substituting an equal amount of methanol for ethanol resulted in increased solute retention, poor detector response, and asymmetrical peaks. Methanol forms a monomolecular layer on octadecyl-derived silica, which may explain the increase in solute retention caused by methanol. Also, the use of methanol would... 

BA, SA Dried roast beef, sugared fruit, mixed with aqueous a-hydroxy-isobutyric acid solution (pH 4.5) and HTA, sonicated/ A/residue washed with aceto-nitrile-H20 (2 3, v/v), /B/, A and B combined Sep-Pak Cl8, 5 yam Acetonitrile-50 mM aqueous a-hydroxy-isobutyric acid (pH 4.5) (2.2 3.4 or 2.4 3.6, v/v) containing 2.5 mM HTA UV 233 nm 81... 

Methanolic solutions of salac (2.04 g, 10 mmol, 20 mL) and aniline (p-chloraniline, MeNH2), (20 mmol) were mixed. To the resulting solution, 0.5mL of piperidine was added and the solution mixture was kept stirred for 4 hr. Then a methanolic solution of CuBr2 [CuCl2, Cu(OAc)2] (10 mmol) was added. A dark solid complex, instantly separated, was filtered, washed with methanol, and dried in air. The complexes were recrystallized from aceto-nitrile/chloroform. 

A mixture of 3-bromoadamantane-l-carboxylic acid (5.8 g), acetonitrile (45 ml) and concentrated sulphuric acid (9 ml) was refluxed for 20 h. After cooling, the mixture was poured into water (250 ml), and the resulting suspension concentrated in vacuo to remove most of the acetonitrile. Aqueous sodium hydroxide (33%) was added until the pH was 4.0 (about 24 ml). The precipitate was filtered off, washed with water, and dried to yield 4.4 g of the 3-acetaminoadamantane-l-carboxylic acid, melting point 254°-258°C (two recrystallizations from methanol-aceto nitrile). 

Fig. 8. Pressure dependence of the endo-exo radio (In relative endo-exo ratio) in the determination of 1,3-cydohexadiene (17 a), sensitized by 1,4-dicyanonaphthalene (21) in aceto-nitrille and benzene [64]...

Verschiedene Phosphorsaure-nucleosidester reagieren als Pyridinium-Salze mit Di-phenyl-disulfan/Tributyl-phosphan (vorzugsweise jeweils 10 Molaquivalente) in Aceto-nitril unter Bildung von Phosphorsaure-O-nucleosidester-S-phenylestern... 

The carbonyl nitrile compound is obtained by reaction between aceto nitrile and an ester... 

An alternative reagent is trichloromethylsilane/sodium iodide in dry aceto-nitrile.76b... 

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