Acetic dichloro

Alcohols (diols, polyols, sugan) Lead(IV) acetate -dichloro fluorescein Diol cleavage of vicinal diols, e. g. sugars, sugar alcohols. The lead tetraacetate consumed is no longer available to decompose the fluorescent dichlorofluorescein. [3, 8]... 

This compound is similar in type to the sodium acet-bromoamide, CHjCONNaBr, which is an intermediate compound in Hofmann s amine synthesis (p. 127). If a weak acid (such as acetic acid) is now added to the solution of the chloro-sodio-amide, the latter compound reacts with the hypo-chlorous acid giving the sulphon-dichloro amide, which being insoluble in water, rapidly separates ... 

Dichloramine-T. Dilute 80 ml, of freshly prepared 2N sodium hypochlorite soluticMi (preparation, p. 525) with 80 ml. of w ter, and then add with stirring 5 g. of finely powdered toluene-p-sulphonamide, a clear solution being rapidly obtained. Cool in ice-water, and then add about 50 ml. of a mixture of equal volumes of glacial acetic acid and water slowly with stirring until precipitation is complete the dichloro-amide separates at first as a fine emulsion, which rapidly forms brittle colourless crystals. Filter off the latter at the pump, wash well with... 

Upon the addition of a weak acid (e.g., acetic acid), it reacts with the liberated hypochlorous acid giving NA -dichloro-p-toluenesulphonamide (dichloramine-T) which, being insoluble in water, crystallises rapidly ... 

Addition occurs rapidly in a variety of solvents including pentane benzene dichloro methane chloroform and acetic acid... 

Pigment YeUow 13 [5102-83-0] 21100 diarjlide coupling of tetra2oti2ed 3,3 -dichloro-ben2idine with aceto acet-2,4- dimethyl-anilide... 

Ghlorohydrination with Nonaqueous Hypochlorous Acid. Because the presence of chloride ions has been shown to promote the formation of the dichloro by-product, it is desirable to perform the chlorohydrination in the absence of chloride ion. For this reason, methods have been reported to produce hypochlorous acid solutions free of chloride ions. A patented method (48) involves the extraction of hypochlorous acid with solvents such as methyl ethyl ketone [78-93-3J, acetonitrile, and ethyl acetate [141-78-6J. In one example hypochlorous acid was extracted from an aqueous brine with methyl ethyl ketone in a 98.9% yield based on the chlorine used. However, when propylene reacted with a 1 Af solution of hypochlorous acid in either methyl ethyl ketone or ethyl acetate, chlorohydrin yields of only 60—70% were obtained (10). 

H-Indole, 3,3-dichloro-synthesis, 4, 369 3H-Indole, 3,3-dimethyl-synthesis, 4, 224 3H-Indole, 3-hydroperoxy-autoxidation, 4, 247 rearrangement, 4, 249 3H-Indole, 3-oximino-synthesis, 4, 209, 210 3H-Indole, 3-oximino-2-phenyl Beckmann rearrangement, 4, 210 Indoleacetic acid synthesis, 4, 337 Indole-3-acetic acid as growth regulator, 4, 372 synthesis, 4, 346 Indole alkaloids, 4, 373 synthesis, 4, 276... 

The relative rates of hydrolysis of acetate, chloro-, dichloro-, and trichloroacetates have been compared and give the following relative rates 1 760 1.6 x 10 10. ... 

Hydrogen sulfide 2,4-Dichloro-phenoxy-acetic add (2-4D) Sulfuric add... 

There are essentially three methods which have been used for incorporation of the glycerol unit in macrobicyclic species. In all of these the pervasive problem is the tendency of glycerol to form five-membered acetals involving the primary and secondary hydroxyls rather than the two primary hydroxyls and the tendency of the glycerol equivalent 1,3-dichloro-2-propanol to form epichlorohydrin. 

Sodium Bismuthate Degradation To a solution of 9a,llj5-dichloro-17a,21-dihydroxypregna-l,4-diene-3,20-dione (1 g) in 50% aqueous acetic acid (800 ml) is added sodium bismuthate (18 g) and the suspension is stirred at room temperature for 20 hr. The reaction mixture is then filtered... 

The crude bromide (10 g) is dissolved in 120 ml of acetone and 12.3 g of anhydrous potassium acetate, 3.8 ml of glacial acetic acid and 5.88 g of sodium iodide are added in that order. The mixture is refluxed with agitation for 4 hr the initial yellow iodine color fades completely during this time. Water (200 ml) is added and the acetone removed by distillation at reduced pressure, whereupon the product separates as bulky fibers. After chilling, the product is collected, washed with water and dried to give 9.4 g (98 %) of 5a,6) -dichloro-3i ,17a,21-trihydroxypregnan-20-one 21-acetate mp 192-195° (dec). 

Cyanoamidines such as (10) are converted into the more useful 2-formyl-A-norsteroids (11) by reduction with lithium in methylamine (buffered with ammonium acetate) followed by hydrolysis on hydrated alumina. This yields a mixture containing approximately 5 parts of the 2j5-aldehyde and 3 parts of the 2a-aldehyde (11). Both aldehydes are smoothly dehydrogenated by 2,3-dichloro-5,6-dicyanobenzoquinone in the presence of acid to the 2-formyl--A-iiorsteroids (12). ... 

Chlorohydnns and 1,2-dichloro denvatives are obtamed by oxidation of alkenes with fert-butyl hypochlorite when the reaction is performed in acetic acid instead of water, chlorohydrm acetate is formed [Ji] (equation 25)... 

Tetrabutylammonium acetate, 20 h, 20°. For comparison, the 2,4-dichloro-phenyl group was removed in 100... 

Factor b above is discussed in Sections II, B, 1 II, B, 4 and II, C. A hydrogen-bonded structure such as 221 can account for the facile reaction of 5-bromouracil or for the unique, so-called hydrolyzability of carboxymethylthio-azines (237). The latter may also react via the intramolecular mechanism indicated in 136. The hydrogen-bonded transition state 238 seems a reasonable explanation of the fact that 3,4,6- and 3,4,5-trichloropyridazines react with glacial acetic acid selectively to give 3-pyridazinones while other nucleophiles (alkoxides, hydrazine, ammonia, or sulfanilamide anion) react at the 4- and 5-positions. In this connection, 4-amino-3,5-dichloro-pyridazine in liquid hydrazine gives (95°, 3hr, 60%yield)the isomer-... 

Chloro-2-hydrazino-4-phenylquinoline A stirred mixture of 2,6-dichloro-4-phenylquino-line 12.7 g,0.01 mol) and hydrazine hydrate (6.8 g) was refluxed under nitrogen for 1 hour and concentrated in vacuo. The residue was suspended in warm water, and the solid was collected by filtration,dried and recrystallized from ethyl acetate-Skelly B hexanes to give 1.81 g (67% yield) of 6[Pg.46]

Five hundred milligrams of (dl)-reg.-Tphenvl-2-dichloroacetamidopropane-1,3-diol is added to a solution consisting of 1 cc of pyridine and 1 cc of acetic anhydride and the resulting reaction mixture heated at 100°C for % hour. The reaction mixture is evaporated to dryness under reduced pressure and the residue taken up in and crystallized from methanol. Recrystallization from methanol produces the pure diacetate of (dl)-reg.-1-phenyl-2-dichloro-acetamidopropane-1,3-diol (MP 94°C). 

A solution of 1.0 g of 1,4 (11 )-pregnatriene-170 1 -diol-3 0-dione-21 -acetate and 5,0 g of lithium chloride in 40 ml of glacial acetic acid is treated with 0.410 g of Nchlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product Is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 90 ,11 -dichloro-1,4-pregnadiene-170 ,21 -diol-3,20-dione-21 -acetate MP 246°C to 253°C (dec.). 

Chemical Name [2,3-dichloro-4-(2-methvlene-1-oxobutvl)phenoxy] acetic acid... 

The oil that separates is extracted with ether, the extract dried over anhydrous sodium sulfate and then evaporated at reduced pressure. The residue is dissolved in boiling benzene (75 ml) treated with decolorizing charcoal, filtered, treated with boiling cyclohexane (275 milliliters) and cooled to give 22.3 grams of 2,3-dichloro-4-butyrylphenoxyacetic acid. After several recrystallizations from a mixture of benzene and cyclohexane, then from methyl-cyclohexane, next from a mixture of acetic acid and water, and finally from methylcyclo-hexane, the product melts at 110° to 111°C (corr). 

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