Phosphono acetic acid

Triethyl phosphonoacetate Acetic acid, phosphono-, triethyl ester (8) ... 

Triethyl phosphonoacetate Acetic acid, phosphono-, triethyl ester (8) Acetic acid, (diethoxyphosphinyl)-, ethyl ester (9) (867-13-0)... 

One of the simplest molecules found to inhibit the repHcation of DNA vimses in animals is phosphonoformic acid [4428-95-9] (PEA, 1) CH O P. Both PEA (as the trisodium salt CNa O P, foscamet [63585-09-1] audits homologue phosphono acetic acid [4408-78-0] (PAA, 2) C2H O P, were developed by Astra Pharmaceuticals (6) and show selective inhibition of DNA polymerase in various herpes vimses. 

Lieb, F., Oediger, H., and Streible, G., Phosphono-Hydroxy-Acetic Acid and Its Salts, Their Production and Their Medicinal Use, U.S. Patent 4,340,599, 1982. 

Ladd. E.C.. Alkyl esters of phosphono bis P-cyanoethylacetic acid and acetic acid nitrile, U.S. Rubber, U.S. Patent Appl. US 2632019. 1953 Chem. Abstr, 48, 1418b, 1954. 

The chiral acetals (10) are attacked by triethyl phosphite at low temperatures in the presence of titanium(IY) chloride to give 1-alkoxyphosphonates (1 la,b) with a high degree of diastereoselecti-vity the main diastereomers (11a) were purified and used to prepare pure (S)-enantiomers of a-aminophosphonic acids. Phosphono-, phenylphosphinico-, and diphenylphosphinoyl-sarcosine (12) have been prepared in improved yields by Arbuzov reactions on the protected sarcosine derivative (13).7... 

Some acyl phosphonates such as phosphonoformic acid (6.298a) have valuable anti-viral or antibiotic properties (Chapter 12.12). Phosphono acetic acid (6.298b) has similar properties. The diethyl compound (6.298c) can serve as a useful source of other P compounds [29]. 

On mild steel, the inhibiting activity and passivation characteristics exerted by carboxy and phosphono groups were determined by gravimetric measurements and electrochemical impedance spectroscopy. The organic chemicals under investigation included nitrilo(triacetic acid) (NTA), phos-phonomethyl-iminodi(acetic acid) (MPIDA), di(phosphonomethyl)glycine (DMPG), and nitrilotri(methyl-phosphonic acid) (ATMP). 

Besides their importance as acylating agents and as reaction partners in ester condensations in carbon-14 syntheses, [ " CJacetic acid and its derivatives are indispensible precursors for a broad spectrum of low molecular weight-labeled building blocks such as alkyl halo[ C] acetates, alkyl phosphono[ " C]acetates, alkyl cyano[ C]acetates, dialkyl [ C]malonates, and alkyl [ CJacetoacetates. In addition to [ C]acetic acid, this section covers the primary derivatives their uses. 

Phenyl /-butyl ether, 46, 89 /3-Phenylcinnamic acid, from benzo-phenone and triethyl phosphono-acetate, 48, 75... 

It has been observed that the lithium salts of phosphono acetates (497) and (498) undergo base catalysed D/H proton exchange and C-OR esterolysis as well as acidic hydrolysis mediated by Th and (Figure 95). ... 

Clglycines and phosphono[ C]acetates. [ CJGlycolic acid (205) is conveniently... 

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