Acetic acid amines

Reaction conditions (a) acetic acid, amines, 120 °C. (b) alkyl amines, 85 °C. (c) sodium oxides (i.e. NaOMe or NaOEt), rt. 

Chemical Name acetamide, acetic acid amine CAS Registry No 60-35-5 Molecular Formula C2H5NO, CH3CONH2 Molecular Weight 59.067 Melting Point (°C) ... 

Several examples were discussed earlier of the use of substituent effects for the elucidation of the mechanisms of silene reactions with nucleophilic reagents. For example, the trends in the rate constants for reaction of the series of 1,1 -diarylsilenes 19a-e with alcohols, acetic acid, amines, methoxytrimethylsilane and acetone all indicate that inductive electron-withdrawing substituents at silicon enhance the reactivity of the Si=C bond, and are consistent with a common reaction mechanism in which reaction is initiated by the formation of an intermediate complex between the silene and the nucleophile. 

The dibromo derivatives 125a and 126a have been prepared by reaction of the unsubstituted amine 125c and the methanesulphonate salt of 126c with excess bromine in acetic acid. Amines 125b and 126b have been converted to the isothiocyanates 125 and 126 by reaction with thiophosgene in a biphasic chloroform-bicarbonate system. The radiochemical purity and the specific radioactivity of the isothiocyanate 125 were 99.9% and 27.4 Ci mmol -1, respectively. The benzimidazole isothiocyanate 126 has been prepared with >95% radiochemical purity and with specific activity of 16.3 Ci mmol -1. 

A variety of alkoxy-azoben/.enes has been appended to C3 of cholesterol to yield a new variety of ALS gelators (e.g., 12-14 named AZOC gelators) 49j. (See Structure 6.) 4 ((Cholestcry loxyJcarbony I )a/.oben/ene (AZOC) derivatives can gel liquids such as ethanol, acetic acid, amines, dichloromethane. ethers. 

Charles JM, Cunny HC, Wilson RD, and Bus JS (1996) Comparative subchronic studies on 2,4-dichlorophenoxy-acetic acid, amine, and ester in rats. Fundamental and Applied Toxicology 33 161-165. 

Examples of such compounds of special interest are formaldehyde, acetaldehyde, acetic acid, amines, diisocyanates, some polycyclic aromatic hydrocarbon, and many biocides (some of these may not be VOCs). Additional examples of such compounds... 

Synonyms Acetic acid amide Acetic acid amine Acetimidic acid Ethanamide Ethanolamide... 

Sodium/alcohol s. under H2C(CNjCOOCg/fs Zinc/acetic acid Amines from hydrazones s. 21,53... 

Acetic acid Amines, aminoacids, salts, weak acids, sulfonoamides HCIO4 in dioxan or acetic acid... 

Platinum oxide acetic acid Amines from nitro compounds... 

Sulfuric acid acetic acid Amines from sulfonic acid amides s. 5,28 s. a. P. D. Carpenter and M. Lennon, Chem. Commun. 1973, 664... 

Startg. m. heated 48 hrs. at 110° in a degassed sealed tube with 3 N KOH in 3 1 methanol-water -> hydrazine deriv. (Y 93%) hydrogenated 24 hrs. at 25° with Adam s catalyst in methanol containing acetic acid amine deriv. Overall Y 85%. - Allylic functionalization of complex molecules can be achieved via the above conversions. E. J. Corey and B. B. Snider, Tetrah. Let. 1973, 3091. 

Hazardous reactions. Hydrogen peroxide vapors can form sensitive contact explosives with hydrocarbons such as greases. Hazardous reactions ranging from ignition to explosion have been reported with alcohols, ketones, carboxylic acids (particularly acetic acid), amines and phosphorus. 

Trade Names Containing DA-16-5% DA-17-5% Panatex K Acetic acid amide Acetic acid amine. See Acetamide Acetic acid, [2-[2-butoxyethoxy] ethoxy]-. See Buteth-2 carboxylic acid Acetic acid, (2-butoxyethoxy)-, sodium salt. See Sodium butoxyethoxy acetate Acetic acid, 2-butoxyethyl ester. See Butoxyethanol acetate Acetic acid, butyl ester Acetic acid n-butyl ester. See n-Butyl acetate Acetic acid, C7-9-branched alkyl esters, C8-rich. See C8 alkyl acetate Acetic acid, C11-14>branched alkyl esters, C13-rich. See C13 alkyl acetate Acetic acid, cobalt (2+) salt. See Cobalt diacetate Acetic acid, cobaH (2+) saH, tetrahydrate. See CobaH acetate (ous)... 

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