Abdominal pain fluconazole

Fluconazole is well tolerated. Nausea, vomiting, abdominal pain, diarrhea, and skin rash have been reported in fewer than 3% of patients. Asymptomatic liver enzyme elevation has been described, and several cases of drug-associated hepatic necrosis have been reported. Alopecia has been reported as a common adverse event in patients receiving prolonged high-dose therapy. Coadministration of fluconazole with phenytoin results in increased serum phenytoin levels. 

Adverse Effects. Hepatotoxicity is the most serious adverse effect of fluconazole this drug should be used cautiously in patients with impaired liver function. Other common side effects include headache and gastrointestinal disturbances (abdominal pain, nausea, vomiting). 

Fluconazole is used for superficial mucosal candidiasis and fungal skin infections. It should be used with caution in patients with renal and hepatic dysfunction. It is reported that teratogenicity is observed in animals hence it is not recommended for use in pregnant women.66 66g Adverse effects include abdominal pain and diarrhea. Alopecia has occasionally been reported in patients during prolonged use.67... 

IMATINIB 1. ANTIBIOTICS - clarithromycin, erythromycin 2. ANTIFUNGALS -fluconazole, itraconazole, ketoconazole voriconazole 3. ANTIVIRALS -efavirenz, ritonavir 4. GRAPEFRUIT JUICE 5. H2 RECEPTOR BLOCKERS - cimetidine t imatinib levels with t risk of toxicity (e.g. abdominal pain, constipation, dyspnoea) and of neurotoxicity (e.g. taste disturbances, dizziness, headache, paraesthesia, peripheral neuropathy) Due to inhibition of CYP3A4-mediated metabolism of imatinib Monitor for clinical efficacy and for the signs of toxicity listed, along with convulsions, confusion and signs of oedema (including pulmonary oedema). Monitor electrolytes and liver function, and for cardiotoxicity... 

FLUCONAZOLE, ITRACONAZOLE, KETOCONAZOLE, VORICONAZOLE (POSSIBLY POSACONAZOLE) VINCA ALKALOIDS -VINBLASTINE, VINCRISTINE, VINORELBINE t adverse effects of vinblastine and vincristine Inhibition of CYP3A4-mediated metabolism. Also inhibition of P-gp efflux of vinblastine Monitor FBCs and watch for early features of toxicity (pain, numbness, tingling in the fingers and toes, jaw pain, abdominal pain, constipation, ileus). Consider selecting an alternative drug... 

Nausea and vomiting are mentioned in most reports of patients taking fluconazole, with an incidence of 10-15% (SED-12, 682) (36,40,41,46,47). Anorexia, mild abdominal pain, and diarrhea have been reported, but none was severe. 

Based on an EMBASE and MEDLINE literature search, data from 90 studies in 4209 subjects were reviewed [13 ]. During the studies, 794 adverse effects were recorded. The most common adverse effect was fluconazole-related hepatotoxicity (47.6%), of which the majority occurred in neonates (295 out of 378 cases). Gastrointestinal symptoms including nausea, vomiting, abdominal pain, diarrhoea, dyspepsia, anorexia and gastritis accounted for 15.4% of all adverse effects. 

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