A genes rearrangement

In differentiation of one antibody-forming clone of cells, a gene rearrangement links one of the approximately 300 V sequences with one of the 4 J sequences. All of the DNA that lies between these two spliced sequences is deleted in this rearrangement and disappears from all progeny of this cell line. Any upstream V sequences (on the 5 side, to the left in Figure 25.32) and downstream J sequences (on the 3 side, to the right) remain in these cells but are not used in antibody synthesis. 

Bonati, A., et al. T-cell receptor beta-chain gene rearrangement and expression during human thymic ontogenesis, Blood, 79, 1472, 1992. 

Many of the Philadelphia-positive adult ALL cases (50-75%) have a different type of gene rearrangement. The gene fusion BCR/c-abl takes place after the breakpoints in intron 1 of the BCR gene and the common sequence of the C-abl gene (H2). 

Komminoth, P., Long, A. A., Ray, R., and Wolfe, H. J. (1992) In situ polymerase chain reaction detection of viral DNA, single copy genes and gene rearrangements in cell suspensions and cytospins. Diag. Mol. Pathol. 1, 85-97. 

Kim H, Choe J, Yoo S et al (2011) Detection of ALK gene rearrangement in non-small-cell lung cancer a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization with correlation of ALK protein expression. I Thorac Oncol 6 1359-1366... 

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