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Rearranging Genes

Three Gene Segments Encode a Light Chain [Pg.5]

When the RSS were first found adjacent to the V and J gene segments encoding light chains, it was pointed out that their structure is reminiscent of inverted repeats [Pg.11]

V and J gene segments were also shown to encode segments of the heavy chain [Pg.12]

V region. However, these two gene segments did not appear to encode the complete [Pg.12]

Removal of a few base pairs at V(D)J junctions occurs frequently. An early suggestion to account for this truncation was that an exonuclease trims the coding ends before they are joined (Alt and Baltimore, 1982), but the enzyme responsible has not yet been identified. Lewis (1994a) has pointed out that it is even possible that trimming results from endonucleolytic rather than exonucleolytic activity. The imprecision in junctional joining, as well as the removal or addition of bases not [Pg.15]

E. The Rearranging Genes for Immunoglobulins andT-Cell Receptor-... [Pg.1861]

Ramsden, D.A. Gellert, M. (1995). Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes and Dev. 9,2409-2420. [Pg.86]

Saccharomyces cerevisiae, 272 Secondary messenger hypothesis, 274 Secondary rearrangement (genes), 51-53... [Pg.304]

Sugawa, N., Ekstrand, A. J., James, C. D., and Collins, V. P. (1990). Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc. Natl. Acad. Sci. U.S.A. 87, 8602-8606. [Pg.421]

Figure 33.16. Light-Chain Expression. The light-chain protein is expressed by transcription of the rearranged gene to produce a pre-RNA molecule with the VJ and C regions separated. RNA splicing removes the intervening sequences to produce an mRNA molecule with the VJ and C regions linked. Translation of the mRNA and processing of the initial protein product produces the light chain. Figure 33.16. Light-Chain Expression. The light-chain protein is expressed by transcription of the rearranged gene to produce a pre-RNA molecule with the VJ and C regions separated. RNA splicing removes the intervening sequences to produce an mRNA molecule with the VJ and C regions linked. Translation of the mRNA and processing of the initial protein product produces the light chain.
In some cases, V-D-J rearrangement will result in combining V, D, and J segments out of frame. mRNA molecules produced from such rearranged genes will produce truncated molecules if translated. This possibility is excluded by degrading the mRNA. [Pg.1509]

Gurtler V (1999) The role of recombination and mutation in 16S-23S rDNA spacer rearrangement. Gene 238 241-252... [Pg.208]

See other pages where Rearranging Genes is mentioned: [Pg.614]    [Pg.374]    [Pg.1830]    [Pg.1859]    [Pg.1859]    [Pg.3]    [Pg.5]    [Pg.6]    [Pg.7]    [Pg.7]    [Pg.8]    [Pg.9]    [Pg.17]    [Pg.17]    [Pg.31]    [Pg.34]    [Pg.41]    [Pg.41]    [Pg.46]    [Pg.48]    [Pg.49]    [Pg.638]    [Pg.196]    [Pg.137]    [Pg.357]    [Pg.614]    [Pg.145]    [Pg.1388]    [Pg.957]    [Pg.972]    [Pg.44]    [Pg.52]    [Pg.626]    [Pg.72]    [Pg.179]    [Pg.917]    [Pg.946]    [Pg.946]    [Pg.948]    [Pg.551]    [Pg.551]   


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A genes rearrangement

Antibodies gene rearrangements

Antigen-receptor gene rearrangements

Gene rearrangements

Gene rearrangements

Immunoglobulins gene rearrangements

Regulation of Gene Rearrangement

The Rearranging Genes for Immunoglobulins and T-Cell Receptors

V genes rearrangement

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