A1B-Adrenergic receptors

Cavalli A, Lattion AL, Hummler E, et al. Decreased blood pressure response in mice deficient of the a1B adrenergic receptor. Proc Natl Acad Sci USA 1997 94 11,589-11,594. 

Porter JE, Perez DM. Characteristics for a salt-bridge switch mutation of the a1B adrenergic receptor—altered pharmacology and rescue of constitutive activity. J Biol Chem 1999 274 34,535-34,538. 

Cavalli A, Fanelli F, Taddei C, DeBenedetti PG, Cotecchia S. Amino acids of the a1B-adrenergic receptor involved in agonist binding differences in docking catecholamines to receptor subtypes. FEBS Lett 1996 399 9-13. 

Porter JE, Hwa J, Perez DM. Activation of the a1B-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint. J Biol Chem 1996 271 28,318-28,323. 

Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S. G-protein-coupled receptor genes as protooncogenes - constitutively activating mutation of the a1B-adrenergic receptor enhances mitogenesis and tumorigenicity. ProcNatl Acad Sci US A 1991 88 11,354-11,358. 

Chen S, Lin F, Xu M, Hwa J, Graham RM. Dominant-negative activity of an a1B-adrenergic receptor signal-inactivating point mutation. EMBO J 2000 19 4265-4271. 

Porter JE, Perez DM. Influence of a lysine 331 counterion on the pKa of aspartic acid 125 Evidence for a salt-bridge interaction and role in a1B-Adrenergic receptor activation. J Pharmacol Exp Ther2000 292 440-448. 

Scheer A, FanelliF, CostaT, DeBenedettiPG, CotecchiaS. Constitutively active mutants of the a1B-adrenergic receptor role of highly conserved polar amino acids in receptor activation. EMBO J 1996 15 3566-3578. 

Blitzer RD, Omri G, Devivo M, et al. Coupling of the expressed a1B-adrenergic receptor to the phospholipase-C pathway in Xenopus oocytes—the role of G0. J Biol Chem 1993 268 7532-7537. 

Horie K, Itoh H, Tsujimoto G. Hamster a1B-adrenergic receptor directly activates Gs in the transfected Chinese-hamster ovary cells. Mol Pharmacol 1995 48 392-400. 

Xu Z, Hirasawa A, Shinoura H, Tsujimoto G. Interaction of the a1B-adrenergic receptor with gClq-R, a multifunctional protein. J Biol Chem 1999 274 21,149-21,154. 

Fonseca MI, Button DC, Brown RD. Agonist regulation of a1B-adrenergic receptor subcellular distribution and function. J Biol Chem 1995 270 8902-8909. 

Toews ML, Prinster SC, Schulte NA. Regulation of a1B adrenergic receptor localization, trafficking, function, and stability. Life Sci 2003 74 379-389. 

Diviani D, Lattion AL, Cotecchia S. Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the a1B-adrenergic receptor. J Biol Chem 1997 272 28,712-28,719. 

Wang J, Wang L, Zheng J, Anderson JL, Toews ML. Identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the hamster a1B-adrenergic receptor. Mol Pharmacol 2000 57 687-694. 

Gao B, Kunos G. Isolation and characterization of the gene encoding the rat a1B adrenergic receptor. Gene 1993 131 243-247. 

O Connell TD, Ishizaka S, Nakamura A, et al. The a1A/c- and a1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest 2003 111 1783-1791. 

Battaglia G, Fomai F, Busceti CL, Lembo G, Nicoletti F, De Blasi A. a1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem 2003 86 413 121. 

Milano CA, Dolber PC, Rockman HA, et al. Myocardial expression of a constitu-tively active a1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci USA 1994 91 10,109-10,113. 

Lemire I, Ducharme A, Tardif JC, et al. Cardiac-directed overexpression of wild-type a1B-adrenergic receptor induces dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 2001 281 H931-H938. 

Grupp IL, Lorenz JN, Walsh RA, Boivin GP, Rindt H. Overexpression of a1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. Am J Physiol 1998 275 H1338-H1350. 

Wang BH, Du XJ, Autelitano DJ, Milano CA, Woodcock EA. Adverse effects of constitutively active a1B-adrenergic receptors after pressure overload in mouse hearts. Am J Physiol Heart Circ Physiol 2000 279 H1079-H1086. 

Akhter SA, Milano CA, Shotwell KF, et al. Transgenic mice with cardiac overexpression of a1B-adrenergic receptors. In vivo aradrenergic receptor-mediated regulation of [J-adrenergic signaling. J Biol Chem 1997 272 21,253-21,259. 

Zuscik MJ, Chalothorn D, Hellard D, et al. Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the a1B-adrenergic receptor. J Biol Chem 2001 276 13,738-13,743. 

Piascik MT, Hrometz SL, Edelmann SE, Guarino RD, Hadley RW, Brown RD. Immunocytochemical localization of the a1B adrenergic receptor and the contribution of this and the other subtypes to vascular smooth muscle contraction analysis with selective ligands and antisense oligonucleotides. J Pharmacol Exp Ther 1997 283 854-868. 

Zuscik MJ, Sands S, Ross S A, et al. Overexpression of the a1B-adrenergic receptor causes apoptotic neurodegeneration multiple system atrophy. Nat Med 2000 6 1388-1394. 

Buscher R, Herrmann V, Ring KM, et al. Variability in phenylephrine response and essential hypertension a search for human a1B-adrenergic receptor polymorphisms. J Pharmacol Exp Ther 1999 291 793-798. 

Changes in Gene Expression in the Hearts of 2- and 12-mo-old Mice Expressing Constitutively Active a1B-Adrenergic Receptors... 

Yun J, Zuscik MJ, Gonzalez-Cabrera P, et al. Gene expression profiling of a1B-adrenergic receptor-induced cardiac hypertrophy by oligonucleotide arrays. Car-diovasc Res 2003 57 443-455. 

Auer KL, Spector MS, Tombes RM, et al. a-Adrenergic inhibition of proliferation in HEPG2 cells stably transfected with the a1B-adrenergic receptor through a p42MAPkinase/p21Cipl/WAFl-dependent pathway. FEBS Lett 1998 436 131-138. 

---