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3a-hydroxy-5a-pregnan-20-one

Cheney DL, Uzunov D, Costa E, Guidotti A. 1995. Gas chromatography-mass fragmentometric quantification of 3a-hydroxy-5a-pregnan-20-one (aUopregnanolone) and its precursor in blood and brain of adrenalectomized and castrated rats. J Neurosci 16 4641-4650. [Pg.190]

Khisti RT, Chopde CT, Jain SP (2000) Antidepressant-like effect of the nemosteroid 3a-hydroxy-5a-pregnan-20-one in mice forced swim test. Pharmacol Biochem Behav 67 137-143... [Pg.521]

Bitran D, Hilvers RJ, Kellogg CK Anxiolytic effects of 3a-hydroxy-5a-pregnan-20-one, endogenous metabolite of progesterone that are active at the GABA receptor. Brain Res 561 157-161, 1991... [Pg.598]

Brinton RD The neurosteroid 3a-hydroxy-5a-pregnan-20-one induces cytoarchi-tectural regression in cultured fetal hippocampal neurons. J Neurosci 14 2763-2774, 1994... [Pg.604]

Corpechot C, Young J, Calvel M, et al 3a-hydroxy-5a-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 133 1003-1009, 1993... [Pg.616]

Kavaliers M, Wiebe JP Analgesic effects of the progesterone metabolite, 3a-hydroxy-5a-pregnan-20-one, and possible modes of action. Brain Res 415 393-398, 1987... [Pg.670]

Norberg L, Wahlstrom G, Backstrom T The anaesthetic potency of 3a-hydroxy-5a-pregnan-20-one and 3a-hydroxy-5b-pregnan-20-one determined with an intravenous EEG-threshold method in male rats. Pharmacol Toxicol 61 42-47, 1987 Nordberg A Human nicotinic receptors-their role in aging and dementia. Neurochem Int 25 93-97, 1994... [Pg.710]

These observations, while implicating steroids in brain function and behaviour, cannot be taken as a reliable indicator of their actual effect on neuronal function. Nevertheless, some neurosteroids produce CNS depression with a rapid inhibition of neuronal excitability and one progesterone derivative, alphaxalone (3a-hydroxy-5a pregnane-11, 20 dione, see Fig. 13.5) has been used effectively as an intravenous anaesthetic in humans. [Pg.275]

The anaesthetic steroid 3a-hydroxy-5a-pregnane-ll,20-dione has normal conformational features, both in the crystal and in solution. X-Ray data show that deoxycholic acid can form an inclusion complex in which alternate molecules of dimethyl sulphoxide and water are held in canals formed by helically arranged host molecules.Six different crystalline forms of 17a-ethynyloestradiol have been recognized. X-Ray structural data are reported for 3-methoxy-2-aza-oestra-l,3,5(10)-trien-17/3-yl acetate, 3/3-hydroxypregn-5-en-20-one (pregnenolone), 5a-cholest-2-ene, 3/3-bromo- and 3/3-chloro-cholest-5-enes, and cholesteryl acetate (at 123 K), benzoate, chloroformate, ° laurate, methyl carbonate, and 24-norcholesteryl acetate. ... [Pg.201]

A series of pregnane-17-thiol derivatives (e.g. 16a-OH-17a-SH, 16/8-OH-17a-SH, and 16/8-OH-17/8-SH derivatives of progesterone, and some of their esters) has been prepared for biological evaluation. 3a,6a-Dihydroxy-5a-pregn-9(ll) en-20-one, isolated from starfish, has been synthesized from 1 la-hydroxy-progesterone. 5-Bromo-6/8 -fluoro-3/8,16a, 17a -trihydroxy-5a -pregnan-20-one... [Pg.297]

Five 20-oxosteioids (pregnenolone, 3 -hydroxy-5a-, 3) -hydrpxy-5) -, 3a-hydropy-5a- and 3-hydroxy-5) -pregnan-20-one) and their sulfates were separated as their 4- A, Ar -dimethylaminosulfonyl)-7-hydrazino-2,l,3-benzoxadiazole derivatives on a Cjg column (A = 450nm, ex 550nm, em). The mobile phase was a 3/1 methanol/water (4mM y-cyclodextrin). Good resolution was obtained and elution was complete in 25 min [422],... [Pg.168]

Pregnene-17a,21-diol-3,20-dione, 38B, 539 39B, 386 Aldosterone monohydrate, 38B, 540, 17/3-Bromoacetoxy-5a-androstan-3-one, 44B, 482, 2/3-Bromo-3a-hydroxy-5a-pregnane-l 1, 20-dione, 46B, 528, 2a-Bromo-17p-acetoxy-9-methyl-5a,9P,1Oa-estran-3-one,... [Pg.258]

The 3/3-azido-A -steroids are obtained on treatment of the 3/5-tosyloxy-A -steroids, or better the 3a,5a-cyclo-6-hydroxy-steroids, with a solution of hydrazoic acid in benzene in the presence of an excess of BFg. Reduction of the azide function is effected with LiAlH4 (Scheme 2). Holaphyllamine (39) has been prepared from 3a,6a-ditosyloxy-5/5-pregnan-20-one (37), by way of the azide (38). The introduction of a 20a-amino-group in a steroid can be effected starting from the corresponding acid and making use of the stereospecificity of the... [Pg.389]

Hydroxy-6-methyl-10 (5 6) abeo-cholestan-5-one acetate, 391 3 a-Hydroxy-16a-methyl-11,20-dioxo-5/3-pregnane-21-glyoxylic acid, 191 17 -Hydroxy-l-niethyl-A-homo-5a-androst-l-en-3-one acetate, 362 17 /3-Hy droxy-5a, 1 Oa-methy lene-A-norestran-3-one, 429 17 3-Hydroxy-17 a-methyl-10 ( 5 4) -fl( < o-estrane-3,5-dione, 314 3a-Hydroxy-16a-methyl-5/3-pregnane-11,20-dione, lyl... [Pg.460]

See other pages where 3a-hydroxy-5a-pregnan-20-one is mentioned: [Pg.237]    [Pg.164]    [Pg.29]    [Pg.440]    [Pg.164]    [Pg.955]    [Pg.202]    [Pg.451]    [Pg.451]    [Pg.438]    [Pg.438]    [Pg.187]    [Pg.303]    [Pg.237]    [Pg.164]    [Pg.29]    [Pg.440]    [Pg.164]    [Pg.955]    [Pg.202]    [Pg.451]    [Pg.451]    [Pg.438]    [Pg.438]    [Pg.187]    [Pg.303]    [Pg.208]    [Pg.47]    [Pg.277]    [Pg.269]    [Pg.167]    [Pg.155]    [Pg.257]    [Pg.233]    [Pg.77]    [Pg.27]    [Pg.112]    [Pg.310]    [Pg.261]    [Pg.459]    [Pg.100]    [Pg.52]    [Pg.27]    [Pg.152]    [Pg.86]   
See also in sourсe #XX -- [ Pg.29 , Pg.30 ]



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3- /?-hydroxy-5a-pregnane-20-one

3a-hydroxy-5 3-pregnan-20-one

5a-Pregnan-3-one

Pregnan

Pregnane

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