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Yolk sac tumor

Ohkawa, K. Tsukada, Y. Hibi, N. Umemoto, N. Hara, T. Selective in vitro and in vivo growth inhibition against human yolk sac tumor cell lines by purified antibody against human alpha-fetoprotein conjugated with mitomycin C via human serum albumin. Cancer Immunol. Immun-other. 1986, 23, 81-86. [Pg.1147]

Serum AFP levels are elevated in hepatocellular carcinomas and malignancies involving ovaries and testes. Yolk sac tumors, which occur more frequently in the ovaries of young women, and girls, and in the testes of boys, raise serum levels of AFP. Serum hCG measurement is also helpful in the diagnosis and management of germ cell tumors. Thus, hCG and AFP are also used as tumor markers. [Pg.924]

Alpha-fetoprotein is present in most yolk sac tumors in patchy distribution, but only focally in some cases of embryonal carcinoma.430.455,462-464 Hepatoid differentiation in germ cell tumors, especially with yolk sac tumors, typically immunostains with alpha-fetoprotein and does not show the immunoprohle of true hepato-cytic differentiation, that is, the biliary pattern of immu-nostaining with polyclonal CEA. [Pg.237]

Yolk sac tumor CAM S.2+, PLAP+, EMA-, alpha-fetoproteln+, OCT3/4-... [Pg.237]

Eglen DE, Ulbright TM. The differential diagnosis of yolk sac tumor and seminoma. Usefulness of cytokeratin, alpha-fetoprotein, and alpha-1-antitrypsin immunoperoxidase reactions. Am J Clin Pathol. 1987 88 328-332. [Pg.254]

Embryonal carcinoma is keratin+, CD30+ yolk sac tumor is keratin+, AFP+ choriocarcinoma is keratin+, EMA+. [Pg.354]

KER, keratin (mixture of monoclonal antibodies) EMA, epithelial membrane antigen VIM, vimentin CALRET, calretinin DES, desmin MSA, muscle-specific actin AFP, alpha fetoprotein SYN, synaptophysin CCA, chromogranin A MESOTH, mesothelioma SCYST, spindle cell yolk sac tumor LMS, leiomyosarcoma SPCCA, spindle cell carcinoma (either primary or metastatic) SYNSC, synovial sarcoma SPCNC, spindle cell neuroendocrine carcinoma FS, fibrosarcoma MFH, malignant fibrous histiocytoma. [Pg.360]

A peculiar variant of primary mediastinal yolk sac tumor (MYST) has been documented by Moran and Suster. Even though it features a predominance of spindle cells, and as such may be confused with the other neoplastic entities cited in this section, sarcomatoid MYST is identical immunohistologically to conventional endoder-mal sinus tumor (described in the previous paragraphs). Reactivity for keratin and AFP is expected in spindlecell MYST. The second of these markers reproducibly... [Pg.362]

Ulbright TM, Young RH. Seminoma with tubular, microcystic, and related patterns A study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol. 2005 29 500-505. [Pg.364]

Moran GA, Suster S. Hepatoid yolk sac tumors of the mediastinum A clinicopathologic and immunohistologic study of four cases. Am J Surg Pathol. 1997 21 1210-1214. [Pg.367]

Rare case reports exist of carcinosarcomas harboring yolk sac tumor " or neuroectodermal elements (including primitive, peripheral neuroectodermal tumor). > When it has been studied, the immunophenotype of these components has been similar to that described in tumors outside the context of carcinosarcoma. [Pg.713]

Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that is expressed in yolk sac tumor and its variants, including hepatoid and endometrioid yolk sac tumor. [Pg.723]

TABLE 18.8 Clear Cell Carcinoma vs. Yolk Sac Tumor ... [Pg.729]

PLAP, placental alkaline phosphatase CDl 1 7 (c-kit), membrane staining CK, cytokeratin, rare dysgerminomas showweak staining, with AEl /AE3 embryonal carcinoma shows membrane staining and yolk sac tumor cytoplasmic staining LCA, leukocyte common antigen MPO, myeloperoxidase. [Pg.737]

FIGURE 18.42 Yolk sac tumor, showing positive staining for AFP. Weak to moderate patchy staining, as shown here, is characteristic. Diffuse strong staining for AFP is unusual. [Pg.738]

FIGURE 18.43 Mixed germ cell tumor. An immunostain for cyto-keratin AE1 /AE3 helps to delineate the various elements. Foci of yolk sac tumor (top) show strong cytoplasmic staining for keratin. The surrounding dysgerminoma is keratin negative. [Pg.738]

FIGURE 18.44 Embryonal carcinoma. An immunostain for CD30 shows strong membrane staining, characteristic of embryonal carcinoma. Staining for cytokeratin AE1/AE3 shows a similar membrane pattern in embryonal carcinoma, as compared to a cytoplasmic pattern of staining in yolk sac tumor (see Figure 18.43). [Pg.738]

Alpha-fetoprotein and glypican-3 are the most useful markers for yolk sac tumor. [Pg.740]

Nogales FF, Bergeron C, Carvia RE, et al. Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm—Analysis of six cases. Am J Surg Pathol. 1996 20 1056-1066. [Pg.752]

Ramalingam P, Malpica A, Silva EG, et al. The use of cytokeratin 7 and EMA in differentiating ovarian yolk sac tumors from endometrioid and clear cell carcinomas. Am J Surg Pathol. 2004 28 1499-1505. [Pg.754]

Esheha GE, Pate LL, Longacre TA. Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary. Am J Surg Pathol. 2008 32 600-607. [Pg.756]

See other pages where Yolk sac tumor is mentioned: [Pg.251]    [Pg.768]    [Pg.236]    [Pg.237]    [Pg.241]    [Pg.351]    [Pg.362]    [Pg.570]    [Pg.644]    [Pg.647]    [Pg.723]    [Pg.728]    [Pg.729]    [Pg.729]    [Pg.736]    [Pg.736]    [Pg.737]    [Pg.737]    [Pg.737]    [Pg.737]    [Pg.737]    [Pg.738]    [Pg.738]    [Pg.215]    [Pg.226]   
See also in sourсe #XX -- [ Pg.255 ]



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