Y-Aminobutyric acid , GABAa

Smith TA. Type A y-aminobutyric acid (GABAa) receptor subunits and benzodiazepine binding significance to... 

List of Abbreviations PCR, polymerase chain reaction RT-PCR, reverse transcription polymerase chain reaction DNA, deoxyribonucleic acid RNA, ribonucleic acid RNase, ribonuclease mRNA, messenger RNA GABAa, y-aminobutyric acid type A cRNA, copy RNA dNTPs, deoxy nucleoside triphosphates MMLV, Mouse Moloney murine leukemia vims RT, reverse transcriptase bp, base pair Tm, melting temperature DEPC, diethylpyrocarbonate OD, optical density mL, milliliter SA-PMPs, streptavidin paramagnetic particles dT, deoxy thymidine DTT, dithiothreitol DNase, deoxyribonuclease RNasin, ribonuclease inhibitor UV, ultraviolet TBE, Tris-borate, 1 mM EDTA EDTA, ethylenediaminetetraacetic acid Buffer RET, guanidium thiocyanate lysis buffer PBS, phosphate buffered saline NT2, Ntera 2 neural progenitor cells... 

Majewska MD, Schwartz RD Pregnenolone-sulfate an endogenous antagonist of the y-aminobutyric acid receptor complex in brain Brain Res 404 355-360, 1987 Majewska MD, Harrison NL, Schwartz RD, et al Steroid hormone metabolites are barbiturate-hke modulators of the GABAa receptor. Science 232 1004-1007, 1986... 

GABAa receptors are another site of action of CPZ (9) in neurons of the central nervous system. Mozrzymas et al. [284] have found that CPZ (9) reduced the amplitude and accelerated the decay of miniature inhibitory post-synaptic currents. Using ultrafast y-aminobutyric acid (GABA) applications and model simulations, they demonstrated that CPZ (9) decreased the binding and increased the unbinding constants of the neurotransmitter to GABAa receptors. 

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