Xeroderma pigmentosum human fibroblast cells

Keyse, S.M., Moss, S.H., and Davies, K.J.G., Action spectra for inactivation of normal and Xeroderma pigmentosum human skin fibroblasts by ultraviolet radiations, Photochem. PhotobioL, 37, 307,1983. Jagger, J., Solar-UV Actions on Living Cells, Praeger, New York, 1985. 

Maher, V., Rowan, L.A., Silinskas, K., Kateley, S., and McCormick, J. (1982). Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells, Proc. Natl. Acad Sd. 79,2613. 

E. coli bacteria4S) and in cultured human cells. In Fig. 21 the survival curves are given for human fibroblasts after treatment with various cispiatin concentrations50 The curves obtained for cells of patients suffering from inherited DNA repair deficiencies, such as xeroderma pigmentosum and Fanconi s anemia, clearly indicate that these cells are more susceptible to the cytotoxic activity of cispiatin than the same type of cells obtained from normal , healthy persons. 

Cells Chinese hamster CHO(SCl), CHO, V79, V79-4, DON, Cl-1, D-6 Syrian hamster BHK mouse 3T3, ME (mouse embryo primary cells) human HPBL (human peripheral blood lymphocytes), NHF (normal human fibroblasts), XP (xeroderma pigmentosum), FA (Fanconi s anemia), BS (Bloom s syndrome) Muntjac. Activation In experiments in which poor metabolizing ability of cells is augmented by an activation system S9 (Ames S-9 Mix), FL (irradiated feeder layer of metabolizing cells). 

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