World Health Organization Essential Drug List

World Health Organization Essential Drug List... 

The Use of Essential Drugs, 6th List, Technical Report Series No. 296, World Health Organization, Geneva, Switzerland, 1990. 

A TLC method/approach that is low cost, maintenance free, fast and reliable, an apparatus that is made of a plastic bag, and that does not require electricity (for developing countries) has been suggested [3J. The feasibility was demonstrated by the analysis of a partial list of the essential drugs established by the World Health Organization. 

Oil-soluble artemether and water-soluble sodium artesunate were developed and approved as new antimalarial drugs by the Chinese authorities in 1987. After 1992, dihydroartemisinin, Coartem (a combination of artemether and benflumetol), and Artekin (a combination of dihydroartemisinin and piperaquine) were also marketed as new antimalarial dmgs. Since then, over 10 million malaria patients on a global scale have been cured after administration of these drugs. As a result, artemether, artesunate, and Coartem were added by the World Health Organization to the ninth, eleventh, and twelfth Essential Medicine List respectively. 

Lindenberg, M., Kopp, S. and Dressman, J.B. (2004) Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. European Journal of Pharmaceutical Sciences, 58 (2), 265. 

Class 1 drugs represent a subset of drugs that is decreasing with time If the orally administered immediate release products in the List of Essential Medicines of the World Health Organization (WHO) are considered, approximately 30% can be considered as class 1 drugs (97,98). However, the proportion of class 1 compounds in the development phase for oral immediate-release formulations at AstraZeneca was less than 10% in 2001 (99), and is sHghtly less than 20% at GlaxoSmithKline (100). 

Many feel that no significant breakthroughs in psychotropic drug developoment have taken place in the past 30 years. The World Health Organization (WHO) List of Essential Drugs has continued... 

It was the top-selling pharmaceutical in the United States from 1969 to 1982, with peak sales in 1978 of 2.3 billion tablets It continues to be an important medication and is on the World Health Organization s Essential Drugs list. 

World Health Organization, The use of essential drugs. Ninth report of the WHO Expert Committee (including the revised Model List of Essential Drugs). WHO Technical Report Series No. 895 WHO Geneva, 2000. 

This entry describes the three most important drugscreening methods in use at this time, for TB, macrolide antibiotics, and drugs from the World Health Organization (WHO) Essential Drug List. All of these are based on thin-layer chromatography (TLC). 

Carhart RE, Smith DH, Venkataraghavan R (1985) Atom pairs as molecular features in structure-activity studies. Definition and application. J Chem Inf Comput Sci 25 64-73 Kuz min VE, Artemenko AG, Muratov EN (2008) Hierarchical QSAR technology on the base of Simplex representation of molecular structure. J Comput Aided Mol Des 22 403 21 Lindenberg M, Kopp S, Dressman JB (2004) Classification of orally administered drugs on the World Health Organization Model list of essential medicines according to the biopharmaceutics classification system. Eur J Pharm Biopharm 58 265-278... 

Amoxicillin is a broad spectrum penicillin antibiotic that was first marketed by Beecham Pharmaceuticals in 1972. A co-formulation with potassium clavulanate, marketed by Beecham in 1981, extended the antibacterial spectrum to include (3-lactamase producing organisms. Amoxicillin is on the World Health Organisation s list of essential drugs. 

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